Human Interleukin 2 (Il2, T-Cell Growth Factor, Tcgf) (2-133) Variant (A1 Deleted, Pro65>Lys, Cys125>Ser), Non-Glycosylated, Produced In Escherichia Coli, Conjugated At N6 Of K65 With A Peg Derivative (30Kda)
Malignant Pleural Mesothelioma
Explore 35 assets in Malignant Pleural Mesothelioma →Floatz Rating
D31/100
Confidence
Indicative
Sponsor
Sanofi
Modality
protein_peptide
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
16Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04914897CT.gov A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma (Pegathor Lung 202) | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Malignant Pleural Mesothelioma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Human Interleukin 2 (Il2, T-Cell Growth Factor, Tcgf) (2-133) Variant (A1 Deleted, Pro65>Lys, Cys125>Ser), Non-Glycosylated, Produced In Escherichia Coli, Conjugated At N6 Of K65 With A Peg Derivative (30Kda) (this asset) | Sanofi | P2 | D · 31 |
| Cis-Diamminedichloroplatinum Ii | AstraZeneca | P2 | BB |
| Carboplatin | AstraZeneca | P2 | BB |
| Fluorouracilum | Memorial Sloan Kettering Cancer Center | P2 | B |
| Pembrolizumab | NuCana plc | P2 | B |
| Atezolizumab | Swiss Cancer Institute | P2 | B |
| Decitabine | National Cancer Institute (NCI) | P1/2 | CCC |
| Immunoglobulin Half-Ig G1-Kappa/Scfv-H-Ch2-Ch3, Anti-(Homo Sapiens Ctla4 (Cytotoxic T-Lymphocyte-Associated Protein 4, Cd152)) And Anti-(Homo Sapienspdcd1 (Programmed Cell Death 1, Pd-1, Pd1, Cd279)), Monoclonal Antibody, Bispecific | M.D. Anderson Cancer Center | P2 | CCC |
| 68Ga-NOTA-AE105 | Rigshospitalet, Denmark | P2 | CCC |
+42 more in the Malignant Pleural Mesothelioma cohort
Other indications for Human Interleukin 2 (Il2, T-Cell Growth Factor, Tcgf) (2-133) Variant (A1 Deleted, Pro65>Lys, Cys125>Ser), Non-Glycosylated, Produced In Escherichia Coli, Conjugated At N6 Of K65 With A Peg Derivative (30Kda)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Esophageal Squamous Cell Carcinoma | — | P2 | C · 33 |
| Gastric Cancer | — | P2 | C · 33 |
| Hepatocellular Carcinoma | — | P2 | C · 33 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Human Interleukin 2 (Il2, T-Cell Growth Factor, Tcgf) (2-133) Variant (A1 Deleted, Pro65>Lys, Cys125>Ser), Non-Glycosylated, Produced In Escherichia Coli, Conjugated At N6 Of K65 With A Peg Derivative (30Kda) in Malignant Pleural Mesothelioma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/human-interleukin-2-il2-t-cell-growth-factor-tcgf-2-133-variant-a1-deleted-pro65lys-cys125ser-non-glycosylated-produced-in-escherichia-coli-conjugated-at-n6-of-k65-with-a-peg-derivative-30kda-malignant-pleural-mesothelioma
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