Human T-Lymphocyte Activation Antigen Cd80 (Activation B7-1 Antigen, Ctla-4 Counter-Receptor B7.1, Cd80) Extracellular Domain Containing Fragment (1-208 In The Current Sequence) Fused Via Peptide Linker <Sup>209</Sup>Gsggggsggggsggggs<Sup>225</Sup> To An Fc Fragment Of Human Immunoglobulin G4 (226-454) [Homo Sapiens Ighg4*01, Hinge Ins<Sup>226</Sup>>A, S<Sup>236</Sup>>P (226-238), Ch2 F<Sup>242</Sup>>A, L<Sup>243</Sup>>A, T<Sup>258</Sup>>Q (239-348), Ch3 M<Sup>436</Sup>>L (349-453), Chs K<Sup>455</Sup>>Del (454)] Fused Via Peptide/ Linker <Sup>455</Sup>Ggggs<Sup>459</Sup> To Human Interleukin-2 (Il-2, T-Cell Growth Factor (Tcgf)) (1-133, 460-592 In The Current Sequence), Variant (R<Sup>38</Sup>>A<Sup>497</Sup>, F<Sup>42</Sup>>A<Sup>501</Sup>), Dimer (234-234', 237-237')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Glycoform Alfa
Non-Small Cell Squamous Lung Carcinoma
Explore 53 assets in Non-Small Cell Squamous Lung Carcinoma →Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
GI Innovation, Inc.
Modality
protein_peptide
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04977453CT.gov GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Non-Small Cell Squamous Lung Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Human T-Lymphocyte Activation Antigen Cd80 (Activation B7-1 Antigen, Ctla-4 Counter-Receptor B7.1, Cd80) Extracellular Domain Containing Fragment (1-208 In The Current Sequence) Fused Via Peptide Linker <Sup>209</Sup>Gsggggsggggsggggs<Sup>225</Sup> To An Fc Fragment Of Human Immunoglobulin G4 (226-454) [Homo Sapiens Ighg4*01, Hinge Ins<Sup>226</Sup>>A, S<Sup>236</Sup>>P (226-238), Ch2 F<Sup>242</Sup>>A, L<Sup>243</Sup>>A, T<Sup>258</Sup>>Q (239-348), Ch3 M<Sup>436</Sup>>L (349-453), Chs K<Sup>455</Sup>>Del (454)] Fused Via Peptide/ Linker <Sup>455</Sup>Ggggs<Sup>459</Sup> To Human Interleukin-2 (Il-2, T-Cell Growth Factor (Tcgf)) (1-133, 460-592 In The Current Sequence), Variant (R<Sup>38</Sup>>A<Sup>497</Sup>, F<Sup>42</Sup>>A<Sup>501</Sup>), Dimer (234-234', 237-237')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Glycoform Alfa (this asset) | GI Innovation, Inc. | P1/2 | CCC · 48 |
| Carboplatin | Gruppo Oncologico Italiano di Ricerca Clinica | P3 | BBB |
| Pembrolizumab | Shanghai Henlius Biotech | P3 | BB |
| Serplulimab | Shanghai Henlius Biotech | P3 | BB |
| Cis-Diamminedichloroplatinum Ii | Gruppo Oncologico Italiano di Ricerca Clinica | P3 | BB |
| Docetaxel | Shanghai Henlius Biotech | P3 | BB |
| Tislelizumab | BeOne Medicines | P3 | BB |
| Catequentinib | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | P3 | BB |
| Olaparib | Merck Sharp & Dohme LLC | P3 | BB |
+42 more in the Non-Small Cell Squamous Lung Carcinoma cohort
Other indications for Human T-Lymphocyte Activation Antigen Cd80 (Activation B7-1 Antigen, Ctla-4 Counter-Receptor B7.1, Cd80) Extracellular Domain Containing Fragment (1-208 In The Current Sequence) Fused Via Peptide Linker <Sup>209</Sup>Gsggggsggggsggggs<Sup>225</Sup> To An Fc Fragment Of Human Immunoglobulin G4 (226-454) [Homo Sapiens Ighg4*01, Hinge Ins<Sup>226</Sup>>A, S<Sup>236</Sup>>P (226-238), Ch2 F<Sup>242</Sup>>A, L<Sup>243</Sup>>A, T<Sup>258</Sup>>Q (239-348), Ch3 M<Sup>436</Sup>>L (349-453), Chs K<Sup>455</Sup>>Del (454)] Fused Via Peptide/ Linker <Sup>455</Sup>Ggggs<Sup>459</Sup> To Human Interleukin-2 (Il-2, T-Cell Growth Factor (Tcgf)) (1-133, 460-592 In The Current Sequence), Variant (R<Sup>38</Sup>>A<Sup>497</Sup>, F<Sup>42</Sup>>A<Sup>501</Sup>), Dimer (234-234', 237-237')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Glycoform Alfa
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Nonpapillary Renal Cell Carcinoma | — | P1/2 | CCC · 48 |
| Urothelial Carcinoma | — | P1/2 | CC · 43 |
| Cervical Cancer | — | P1/2 | CC · 41 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Human T-Lymphocyte Activation Antigen Cd80 (Activation B7-1 Antigen, Ctla-4 Counter-Receptor B7.1, Cd80) Extracellular Domain Containing Fragment (1-208 In The Current Sequence) Fused Via Peptide Linker <Sup>209</Sup>Gsggggsggggsggggs<Sup>225</Sup> To An Fc Fragment Of Human Immunoglobulin G4 (226-454) [Homo Sapiens Ighg4*01, Hinge Ins<Sup>226</Sup>>A, S<Sup>236</Sup>>P (226-238), Ch2 F<Sup>242</Sup>>A, L<Sup>243</Sup>>A, T<Sup>258</Sup>>Q (239-348), Ch3 M<Sup>436</Sup>>L (349-453), Chs K<Sup>455</Sup>>Del (454)] Fused Via Peptide/ Linker <Sup>455</Sup>Ggggs<Sup>459</Sup> To Human Interleukin-2 (Il-2, T-Cell Growth Factor (Tcgf)) (1-133, 460-592 In The Current Sequence), Variant (R<Sup>38</Sup>>A<Sup>497</Sup>, F<Sup>42</Sup>>A<Sup>501</Sup>), Dimer (234-234', 237-237')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Glycoform Alfa in Non-Small Cell Squamous Lung Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/human-t-lymphocyte-activation-antigen-cd80-activation-b7-1-antigen-ctla-4-counter-receptor-b71-cd80-extracellular-domain-containing-fragment-1-208-in-the-current-sequence-fused-via-peptide-linker-sup209supgsggggsggggsggggssup225sup-to-an-fc-fragment-of-human-immunoglobulin-g4-226-454-homo-sapiens-ighg401-hinge-inssup226supa-ssup236supp-226-238-ch2-fsup242supa-lsup243supa-tsup258supq-239-348-ch3-msup436supl-349-453-chs-ksup455supdel-454-fused-via-peptide-linker-sup455supggggssup459sup-to-human-interleukin-2-il-2-t-cell-growth-factor-tcgf-1-133-460-592-in-the-current-sequence-variant-rsup38supasup497sup-fsup42supasup501sup-dimer-234-234-237-237-bisdisulfide-produced-in-chinese-hamster-ovary-cho-cells-glycoform-alfa-non-small-cell-squamous-lung-carcinoma
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