Hydrochlorothiazide
Abdominal Obesity-Metabolic Syndrome
Explore 42 assets in Abdominal Obesity-Metabolic Syndrome →Floatz Rating
BB69/100
Confidence
Indicative
Sponsor
UMC Utrecht
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
67High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04934228CT.gov Mitigating the Pro-inflammatory Phenotype of Obesity | — | Recruiting | — | — | — |
NCT01138423CT.gov Treatment of Adiposity Related hypErTension (TARGET) | — | Completed | — | — | — |
NCT00574834CT.gov Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes | — | Terminated | — | — | — |
NCT00170937CT.gov A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Abdominal Obesity-Metabolic Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Hydrochlorothiazide (this asset) | UMC Utrecht | Approved | BB · 69 |
| Atorvastatin | Seoul National University Hospital | P4 | BBB |
| Topiramate | All India Institute of Medical Sciences, Bhubaneswar | P4 | BBB |
| Pioglitazone | Philip Kern | P4 | BBB |
| Rosuvastatin | Hamdard University | P4 | BBB |
| Simvastatin | Jaime Daniel Mondragon | P4 | BBB |
| Olmesartan Medoxomil | Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company | P4 | BBB |
| Amlodipine | Italo Biaggioni | P4 | BB |
| Ezetimibe | Samsung Medical Center | P4 | BB |
+42 more in the Abdominal Obesity-Metabolic Syndrome cohort
Other indications for Hydrochlorothiazide
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Essential Hypertension | — | P4 | BBB · 77 |
| Hypertensive Disorder | — | P4 | BBB · 77 |
| Cardiovascular Disorder | — | P4 | BBB · 72 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Hydrochlorothiazide in Abdominal Obesity-Metabolic Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/hydrochlorothiazide-abdominal-obesity-metabolic-syndrome
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