ICP34.5-, ICP47-DELETED HERPES SIMPLEX VIRUS 1 (HSV-1) INCORPORATING THE HUMAN GM-CSF GENE
Cutaneous Neuroendocrine Carcinoma
Explore 45 assets in Cutaneous Neuroendocrine Carcinoma →Floatz Rating
B59/100
Confidence
Indicative
Sponsor
University of Zurich
Modality
gene_therapy
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
46High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03458117CT.gov T-VEC in Non-melanoma Skin Cancer | — | Completed | — | — | — |
NCT02978625CT.gov Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers | — | Active Not Recruiting | — | — | — |
NCT02819843CT.gov A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Cutaneous Neuroendocrine Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| ICP34.5-, ICP47-DELETED HERPES SIMPLEX VIRUS 1 (HSV-1) INCORPORATING THE HUMAN GM-CSF GENE (this asset) | University of Zurich | P2 | B · 59 |
| Pembrolizumab | Merck Sharp & Dohme LLC | P3 | BB |
| Cyclophosphamide | Merck Sharp & Dohme LLC | P2/3 | BB |
| Ifx-Hu2.0 | TuHURA Biosciences, Inc. | P2/3 | B |
| Fludarabine | Sotio Biotech Inc. | P2 | B |
| Atezolizumab | Ariceum Therapeutics GmbH | P2 | B |
| Durvalumab | Ariceum Therapeutics GmbH | P2 | B |
| Nivolumab | Fred Hutchinson Cancer Center | P2 | B |
| Immunoglobulin G4, Anti-(Human Programmed Cell Death Protein 1) (Human Monoclonal Regn2810 Heavy Chain), Disulfide With Human Monoclonal Regn2810 .Kappa.-Chain, Dimer | Sensei Biotherapeutics, Inc. | P2 | B |
+42 more in the Cutaneous Neuroendocrine Carcinoma cohort
Other indications for ICP34.5-, ICP47-DELETED HERPES SIMPLEX VIRUS 1 (HSV-1) INCORPORATING THE HUMAN GM-CSF GENE
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Melanoma | — | P3 | B · 62 |
| Breast Carcinoma | — | P2 | B · 58 |
| Cutaneous Melanoma | — | P3 | B · 58 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. ICP34.5-, ICP47-DELETED HERPES SIMPLEX VIRUS 1 (HSV-1) INCORPORATING THE HUMAN GM-CSF GENE in Cutaneous Neuroendocrine Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/icp345-icp47-deleted-herpes-simplex-virus-1-hsv-1-incorporating-the-human-gm-csf-gene-cutaneous-neuroendocrine-carcinoma
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