Floatz Rating
B60/100
Confidence
Indicative
Sponsor
Shanghai Pulmonary Hospital, Shanghai, China
Modality
monoclonal_antibody
Development Phase
Phase 2/3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06020352CT.gov The Efficacy and Safety of KN046 Combined With Axitinib | — | Unknown | — | — | — |
NCT05420220CT.gov Study of KN046 in Subjects With Advanced Non-Small Cell Lung Cancer | — | Completed | — | — | — |
NCT05001724CT.gov KN046 Plus Lenvatinib in Subject With Advanced Non-Small Cell Lung Cancer in the Failure of Anti-PD-(L)1 Agent | — | Terminated | — | — | — |
NCT04054531CT.gov Study of KN046 With Chemotherapy in First Line Advanced NSCLC | — | Unknown | — | — | — |
NCT03838848CT.gov KN046 in Patients With Advanced Non-small Cell Lung Cancer | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Non-Small Cell Lung Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Erfonrilimab (this asset) | Shanghai Pulmonary Hospital, Shanghai, China | P2/3 | B · 60 |
| Necitumumab | Jonsson Comprehensive Cancer Center | P3 | BBB |
| Glumetinib | Shanghai JMT-Bio Inc. | P3 | BBB |
| Veliparib | AbbVie | P3 | BBB |
| d-0316 | Betta Pharmaceuticals Co., Ltd. | P2/3 | BBB |
| Icotinib | The First Affiliated Hospital of Guangzhou Medical University | P4 | BBB |
| Zoledronate | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | P4 | BBB |
| Onartuzumab | Hoffmann-La Roche | P3 | BBB |
| Avitinib | Hangzhou ACEA Pharmaceutical Research Co., Ltd. | P3 | BBB |
+42 more in the Non-Small Cell Lung Carcinoma cohort
Other indications for Erfonrilimab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hepatocellular Carcinoma | — | P2 | B · 62 |
| Squamous Cell Lung Carcinoma | — | P3 | B · 59 |
| Biliary Tract Cancer | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Erfonrilimab in Non-Small Cell Lung Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g-266-serine-bispecific-anti-human-programmed-death-ligand-1-human-camelus-bactrianus-monoclonal-kn046-gamma-chain-v-d-j-region-fusion-protein-with-peptide-linker-gap-fusion-protein-with-immunoglobulin-g-anti-human-cytotoxic-t-lymphocyte-associated-protein-4-human-camelus-bactrianus-monoclonal-kn046-gamma-chain-v-d-j-region-fusion-protein-with-peptide-linker-gs-fusion-protein-with-immunoglobulin-g1-human-gamma1-chain-c-region-c-terminal-fragment-dimer-non-small-cell-lung-carcinoma
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