Immunoglobulin G1 [143-Aspartic Acid,236-Glutamic Acid], Anti-(Human Cytotoxic T-Lymphocyte-Associated Protein 4) (Human Monoclonal Hbm4003 Heavy Chain V-D-J Region) Fusion Protein With Immunoglobulin G1 (Human ?1-Chain C Region), Dimer
Neoplasm
Explore 890 assets in Neoplasm →Floatz Rating
C37/100
Confidence
Indicative
Sponsor
Harbour BioMed (Guangzhou) Co. Ltd.
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05167071CT.gov HBM4003 Combine With Toripalimab in Patients With Advanced NEN and Other Solid Tumors Study | — | Active Not Recruiting | — | — | — |
NCT05149027CT.gov A Study to Evaluate Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 Combine With Toripalimab in Patients With Advanced HCC and Other Solid Tumors | — | Unknown | — | — | — |
NCT04866485CT.gov A Study to Evaluate Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 Combined With Anti-PD-1 Antibody | — | Unknown | — | — | — |
NCT04727164CT.gov Study Investigating Safety,Tolerability,Pharmacokinetics and Antitumor Activities of HBM4003 Combine With Toripalimab | — | Unknown | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Neoplasm
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G1 [143-Aspartic Acid,236-Glutamic Acid], Anti-(Human Cytotoxic T-Lymphocyte-Associated Protein 4) (Human Monoclonal Hbm4003 Heavy Chain V-D-J Region) Fusion Protein With Immunoglobulin G1 (Human ?1-Chain C Region), Dimer (this asset) | Harbour BioMed (Guangzhou) Co. Ltd. | P1 | C · 37 |
| Panitumumab | Astellas Pharma Inc | P2 | BBB |
| Granulocyte Colony-Stimulating Factor Lenograstim | Sanofi | P4 | BB |
| Dexmedetomidine | Medical College of Wisconsin | P4 | BB |
| Lidocaine | Medical College of Wisconsin | P4 | BB |
| Relatlimab | Bristol-Myers Squibb | P2 | BB |
| Vitamin D | Tanta University | P4 | BB |
| Glycopyrrolate | Medical College of Wisconsin | P4 | BB |
| Dinitrogen Monoxide | Medical College of Wisconsin | P4 | BB |
+42 more in the Neoplasm cohort
Other indications for Immunoglobulin G1 [143-Aspartic Acid,236-Glutamic Acid], Anti-(Human Cytotoxic T-Lymphocyte-Associated Protein 4) (Human Monoclonal Hbm4003 Heavy Chain V-D-J Region) Fusion Protein With Immunoglobulin G1 (Human ?1-Chain C Region), Dimer
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Colorectal Cancer | — | P1 | CC · 41 |
| Neuroendocrine Neoplasm | — | P1 | C · 39 |
| Cancer | — | P1 | C · 39 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G1 [143-Aspartic Acid,236-Glutamic Acid], Anti-(Human Cytotoxic T-Lymphocyte-Associated Protein 4) (Human Monoclonal Hbm4003 Heavy Chain V-D-J Region) Fusion Protein With Immunoglobulin G1 (Human ?1-Chain C Region), Dimer in Neoplasm. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g1-143-aspartic-acid236-glutamic-acid-anti-human-cytotoxic-t-lymphocyte-associated-protein-4-human-monoclonal-hbm4003-heavy-chain-v-d-j-region-fusion-protein-with-immunoglobulin-g1-human-1-chain-c-region-dimer-neoplasm
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