Immunoglobulin G1 [De-451-Lysine], Anti-(Human/Macaca Fascicularis/Macaca Mulatta/Chlorocebus Sabaeus Mhc Class I Chain-Related Protein Mica/Mhc Class I Chain-Related Protein Micb) (Human-Mus Musculus Monoclonal Cln-619 ?1-Chain), Disulfide With Human-Mus Musculus Monoclonal Cln-619 [34-Leucine] ?-Chain, Dimer
Plasma Cell Myeloma
Explore 475 assets in Plasma Cell Myeloma →Floatz Rating
C36/100
Confidence
Indicative
Sponsor
Cullinan Therapeutics Inc.
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06381141CT.gov A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Plasma Cell Myeloma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G1 [De-451-Lysine], Anti-(Human/Macaca Fascicularis/Macaca Mulatta/Chlorocebus Sabaeus Mhc Class I Chain-Related Protein Mica/Mhc Class I Chain-Related Protein Micb) (Human-Mus Musculus Monoclonal Cln-619 ?1-Chain), Disulfide With Human-Mus Musculus Monoclonal Cln-619 [34-Leucine] ?-Chain, Dimer (this asset) | Cullinan Therapeutics Inc. | P1 | C · 36 |
| Vincristine Sulfate | Roswell Park Cancer Institute | P3 | BBB |
| Hyaluronidase Fihj | Massachusetts General Hospital | P4 | BBB |
| Filanesib | PETHEMA Foundation | P2 | BBB |
| Cyclosporin A | Seoul National University Hospital | P3 | BBB |
| Prednisone | GlaxoSmithKline | P4 | BB |
| Adriamycin | GlaxoSmithKline | P4 | BB |
| Cis-Diamminedichloroplatinum Ii | Janssen Research & Development, LLC | P4 | BB |
| Thalidomide | Institute of Hematology & Blood Diseases Hospital, China | P4 | BB |
+42 more in the Plasma Cell Myeloma cohort
Other indications for Immunoglobulin G1 [De-451-Lysine], Anti-(Human/Macaca Fascicularis/Macaca Mulatta/Chlorocebus Sabaeus Mhc Class I Chain-Related Protein Mica/Mhc Class I Chain-Related Protein Micb) (Human-Mus Musculus Monoclonal Cln-619 ?1-Chain), Disulfide With Human-Mus Musculus Monoclonal Cln-619 [34-Leucine] ?-Chain, Dimer
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Small Cell Lung Carcinoma | — | P1 | C · 37 |
| Cancer | — | P1 | C · 36 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G1 [De-451-Lysine], Anti-(Human/Macaca Fascicularis/Macaca Mulatta/Chlorocebus Sabaeus Mhc Class I Chain-Related Protein Mica/Mhc Class I Chain-Related Protein Micb) (Human-Mus Musculus Monoclonal Cln-619 ?1-Chain), Disulfide With Human-Mus Musculus Monoclonal Cln-619 [34-Leucine] ?-Chain, Dimer in Plasma Cell Myeloma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g1-de-451-lysine-anti-humanmacaca-fascicularismacaca-mulattachlorocebus-sabaeus-mhc-class-i-chain-related-protein-micamhc-class-i-chain-related-protein-micb-human-mus-musculus-monoclonal-cln-619-1-chain-disulfide-with-human-mus-musculus-monoclonal-cln-619-34-leucine-chain-dimer-plasma-cell-myeloma
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