Immunoglobulin G1-Kappa, Anti-[Homo Sapiens Mstn (Myostatin, Growth Differentiation Factor 8, Gdf8, Gdf-8) Latent Myostatin Complex], Humanized Monoclonal Antibody;
Type 2 Diabetes Mellitus
Explore 135 assets in Type 2 Diabetes Mellitus →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Hoffmann-La Roche
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07137585CT.gov A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Type 2 Diabetes Mellitus
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G1-Kappa, Anti-[Homo Sapiens Mstn (Myostatin, Growth Differentiation Factor 8, Gdf8, Gdf-8) Latent Myostatin Complex], Humanized Monoclonal Antibody; (this asset) | Hoffmann-La Roche | P1 | CC · 43 |
| Liraglutide | RenJi Hospital | P4 | BBB |
| Semaglutide | Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Exenatide | Vivani Medical, Inc | P4 | BBB |
| Dapagliflozin | Bhavya Bhavya, MD | P4 | BBB |
| Cotadutide | AstraZeneca | P2 | BBB |
| Metformin | Myopharm Limited | P4 | BBB |
| Saxagliptin | Nick Giannoukakis, PhD | P4 | BBB |
| Orlistat | Affiliated Hospital of Nantong University | P4 | BBB |
+41 more in the Type 2 Diabetes Mellitus cohort
Other indications for Immunoglobulin G1-Kappa, Anti-[Homo Sapiens Mstn (Myostatin, Growth Differentiation Factor 8, Gdf8, Gdf-8) Latent Myostatin Complex], Humanized Monoclonal Antibody;
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Spinal Muscular Atrophy | — | P2/3 | B · 57 |
| Obesity Disorder | — | P2 | CCC · 50 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G1-Kappa, Anti-[Homo Sapiens Mstn (Myostatin, Growth Differentiation Factor 8, Gdf8, Gdf-8) Latent Myostatin Complex], Humanized Monoclonal Antibody; in Type 2 Diabetes Mellitus. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g1-kappa-anti-homo-sapiens-mstn-myostatin-growth-differentiation-factor-8-gdf8-gdf-8-latent-myostatin-complex-humanized-monoclonal-antibody-type-2-diabetes-mellitus
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