Immunoglobulin G4 [237-Proline,242-Proline,243-Valine,244-Alanine,De-245-Glycine], Anti-(Human Mucin-16) (Human Monoclonal Regn5668 ?4-Chain), Disulfide With Human Monoclonal Regn5668 ?-Chain, (235?228?),(238?231?)-Bis(Disulfide) With Immunoglobulin G4 [230-Proline,235-Proline,236-Valine,237-Alanine,De-238-Glycine,436-Arginine,437-Phenylalanine,446-Proline] Anti-(Human Cd28 Antigen) (Human Monoclonal Regn5668 ?4-Chain) Disulfide With Human Monoclonal Regn5668 ?-Chain
Endometrial Carcinoma
Explore 231 assets in Endometrial Carcinoma →Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
Regeneron Pharmaceuticals
Modality
monoclonal_antibody
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04590326CT.gov A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Endometrial Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G4 [237-Proline,242-Proline,243-Valine,244-Alanine,De-245-Glycine], Anti-(Human Mucin-16) (Human Monoclonal Regn5668 ?4-Chain), Disulfide With Human Monoclonal Regn5668 ?-Chain, (235?228?),(238?231?)-Bis(Disulfide) With Immunoglobulin G4 [230-Proline,235-Proline,236-Valine,237-Alanine,De-238-Glycine,436-Arginine,437-Phenylalanine,446-Proline] Anti-(Human Cd28 Antigen) (Human Monoclonal Regn5668 ?4-Chain) Disulfide With Human Monoclonal Regn5668 ?-Chain (this asset) | Regeneron Pharmaceuticals | P1/2 | CC · 41 |
| Indocyanine Green | Istanbul University | P4 | BB |
| Adriamycin | AstraZeneca | P3 | BB |
| Palbociclib | University Medical Center Groningen | P4 | BB |
| Olaparib | Qilu Pharmaceutical Co., Ltd. | P4 | BB |
| Nivestim | Mayo Clinic | P3 | B |
| Docetaxel | Merck Sharp & Dohme LLC | P3 | B |
| Pembrolizumab | Eikon Therapeutics | P3 | B |
| Rilvegostomig | AstraZeneca | P3 | B |
+42 more in the Endometrial Carcinoma cohort
Other indications for Immunoglobulin G4 [237-Proline,242-Proline,243-Valine,244-Alanine,De-245-Glycine], Anti-(Human Mucin-16) (Human Monoclonal Regn5668 ?4-Chain), Disulfide With Human Monoclonal Regn5668 ?-Chain, (235?228?),(238?231?)-Bis(Disulfide) With Immunoglobulin G4 [230-Proline,235-Proline,236-Valine,237-Alanine,De-238-Glycine,436-Arginine,437-Phenylalanine,446-Proline] Anti-(Human Cd28 Antigen) (Human Monoclonal Regn5668 ?4-Chain) Disulfide With Human Monoclonal Regn5668 ?-Chain
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Primary Peritoneal Carcinoma | — | P1/2 | CC · 43 |
| Fallopian Tube Cancer | — | P1/2 | CC · 41 |
| Ovarian Cancer | — | P1/2 | CC · 40 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G4 [237-Proline,242-Proline,243-Valine,244-Alanine,De-245-Glycine], Anti-(Human Mucin-16) (Human Monoclonal Regn5668 ?4-Chain), Disulfide With Human Monoclonal Regn5668 ?-Chain, (235?228?),(238?231?)-Bis(Disulfide) With Immunoglobulin G4 [230-Proline,235-Proline,236-Valine,237-Alanine,De-238-Glycine,436-Arginine,437-Phenylalanine,446-Proline] Anti-(Human Cd28 Antigen) (Human Monoclonal Regn5668 ?4-Chain) Disulfide With Human Monoclonal Regn5668 ?-Chain in Endometrial Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g4-237-proline242-proline243-valine244-alaninede-245-glycine-anti-human-mucin-16-human-monoclonal-regn5668-4-chain-disulfide-with-human-monoclonal-regn5668-chain-235228238231-bisdisulfide-with-immunoglobulin-g4-230-proline235-proline236-valine237-alaninede-238-glycine436-arginine437-phenylalanine446-proline-anti-human-cd28-antigen-human-monoclonal-regn5668-4-chain-disulfide-with-human-monoclonal-regn5668-chain-endometrial-carcinoma
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