Floatz Rating
CCC51/100
Confidence
Indicative
Sponsor
Implicit Bioscience
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03508453CT.gov IC14 for Treatment of Amyotrophic Lateral Sclerosis | — | Withdrawn | — | — | — |
NCT03474263CT.gov IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS) | — | Withdrawn | — | — | — |
NCT03487263CT.gov Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease | — | Completed | — | — | — |
NCT04309604CT.gov IC14 for ALS Patients Expanded Access | — | No Longer Available | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Amyotrophic Lateral Sclerosis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Atibuclimab (this asset) | Implicit Bioscience | P2 | CCC · 51 |
| Taurursodiol | Amylyx Pharmaceuticals Inc. | P3 | BBB |
| Tofersen | Biogen | P4 | BBB |
| Riluzole | AB Science | P4 | BB |
| Mexiletine | Bjorn Oskarsson, MD | P4 | BB |
| Diacetyl(N(4)-Methylthiosemicarbazonato) Copper (Ii) | Collaborative Medicinal Development Pty Limited | P2/3 | BB |
| mt-1186 | Tanabe Pharma Corporation | P3 | BB |
| Autologous Mesenchymal Stromal Cells Secreting Neurotrophic Factors | Brainstorm-Cell Therapeutics | P3 | BB |
| Kns-760704 | Knopp Biosciences | P3 | BB |
+42 more in the Amyotrophic Lateral Sclerosis cohort
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Atibuclimab in Amyotrophic Lateral Sclerosis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g4-anti-human-cd14-antigen-human-mus-musculus-monoclonal-ic14-gamma4-chain-disulfide-with-human-mus-musculus-monoclonal-ic14-kappa-chain-dimer-amyotrophic-lateral-sclerosis
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