Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment)
Non-Hodgkin Lymphoma
Explore 373 assets in Non-Hodgkin Lymphoma →Floatz Rating
CC42/100
Confidence
Indicative
Sponsor
Janssen Research & Development, LLC
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06788509CT.gov A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring | — | Enrolling By Invitation | — | — | — |
NCT06660563CT.gov A Study of JNJ-80948543 in Combination With Other CD3 T-Cell Engagers in Participants With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R B-Cell NHL) | — | Active Not Recruiting | — | — | — |
NCT06139406CT.gov A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer | — | Active Not Recruiting | — | — | — |
NCT04540796CT.gov A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Non-Hodgkin Lymphoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment) (this asset) | Janssen Research & Development, LLC | P1 | CC · 42 |
| Cyclosporin A | Memorial Sloan Kettering Cancer Center | P3 | BBB |
| Pegaspargase | Ciusss de L'Est de l'Île de Montréal | P4 | BBB |
| Adriamycin | National Cancer Institute (NCI) | P4 | BBB |
| Prednisolone | Mwanasha Merrill, MD | P3 | BBB |
| Entecavir | Fudan University | P4 | BBB |
| Cyclophosphamide | National Cancer Institute (NCI) | P4 | BBB |
| Rituximab | National Cancer Institute (NCI) | P4 | BBB |
| Prednisone | National Cancer Institute (NCI) | P3 | BBB |
+42 more in the Non-Hodgkin Lymphoma cohort
Other indications for Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| B-Cell Chronic Lymphocytic Leukemia | — | P1 | CC · 44 |
| Acute Myeloid Leukemia | — | P1 | CC · 41 |
| Castration-Resistant Prostate Carcinoma | — | P1 | CC · 41 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G4, Anti-(Human Cd3 Antigen) (Recombinant Human Monoclonal Jnj-75348780 ?4-Chain), Disulfide With Recombinant Human Monoclonal Jnj-75348780 ? Chain, (229?126?),(232?129?)-Bis(Disulfide) With Immunoglobulin, Anti-(Human Sialic Acid-Binding Ig-Like Lectin 2) (Recombinant Human Single-Domain Vhh Fragment) in Non-Hodgkin Lymphoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g4-anti-human-cd3-antigen-recombinant-human-monoclonal-jnj-75348780-4-chain-disulfide-with-recombinant-human-monoclonal-jnj-75348780-chain-229126232129-bisdisulfide-with-immunoglobulin-anti-human-sialic-acid-binding-ig-like-lectin-2-recombinant-human-single-domain-vhh-fragment-non-hodgkin-lymphoma
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