Immunoglobulin G4-Kappa, Anti-(Human Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 (Ec:3.2.2.6) (Adprc 1/Cadrp Hydrolase 1, Cell Surface Antigen Cd38)), Humanized Monoclonal Antibody, Fused At Each C-Terminus Of The Heavy Chains (1-447, 1''-447'') To Attenuated Human Interferon .Alpha.-2B (Ifn.Alpha.2B) Variant (K23>R470, T106>A553, A145>D592) (448-612, 448''-612''); Gamma4 Heavy Chain Humanized Fused To Ifn.Alpha.2B (1-612) (Vh (Homo Sapiens Ighv1-69-2*01 (90.7%)-(Ighd)-Ighj4*01 (85.7%)) Cdrimgt (8.8.13) (26-33.51-58.97-109) (1-120)-Homo Sapiens Ighg4*01, G4V5 H P10 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 (231-340), Ch3 (341-445), Chs (446-447))(121-447), Fused To Ifn.Alpha.2B K23>R (470), T106>A (553), A145>D (592) (448-612)),(134-214')-Disulfide With Kappa Light Chain Humanized (1'-214') (V-Kappa (Homo Sapiens Igkv1-33*01 (83.2%)-Igkj4*01 (100%)) Cdr-Imgt (6.3.9) (27-32.50-52.89-97) (1'-107')-Homo Sapiens Igkc*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')); Dimer (226-226'':229-229'')-Bisdisulfide; Produced In Chinese Hamster Ovary (Cho) K1Sv Cells, Glycoform Alfa
Plasma Cell Myeloma
Explore 475 assets in Plasma Cell Myeloma →Floatz Rating
D26/100
Confidence
Indicative
Sponsor
Teva Branded Pharmaceutical Products R&D LLC
Modality
monoclonal_antibody
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
15Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05590377CT.gov A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma | — | Terminated | — | — | — |
NCT05556616CT.gov A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma | — | Terminated | — | — | — |
NCT03215030CT.gov A Study of Modakafusp Alfa on Adult Participants With Relapsed/Refractory Multiple Myeloma | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Plasma Cell Myeloma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin G4-Kappa, Anti-(Human Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 (Ec:3.2.2.6) (Adprc 1/Cadrp Hydrolase 1, Cell Surface Antigen Cd38)), Humanized Monoclonal Antibody, Fused At Each C-Terminus Of The Heavy Chains (1-447, 1''-447'') To Attenuated Human Interferon .Alpha.-2B (Ifn.Alpha.2B) Variant (K23>R470, T106>A553, A145>D592) (448-612, 448''-612''); Gamma4 Heavy Chain Humanized Fused To Ifn.Alpha.2B (1-612) (Vh (Homo Sapiens Ighv1-69-2*01 (90.7%)-(Ighd)-Ighj4*01 (85.7%)) Cdrimgt (8.8.13) (26-33.51-58.97-109) (1-120)-Homo Sapiens Ighg4*01, G4V5 H P10 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 (231-340), Ch3 (341-445), Chs (446-447))(121-447), Fused To Ifn.Alpha.2B K23>R (470), T106>A (553), A145>D (592) (448-612)),(134-214')-Disulfide With Kappa Light Chain Humanized (1'-214') (V-Kappa (Homo Sapiens Igkv1-33*01 (83.2%)-Igkj4*01 (100%)) Cdr-Imgt (6.3.9) (27-32.50-52.89-97) (1'-107')-Homo Sapiens Igkc*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')); Dimer (226-226'':229-229'')-Bisdisulfide; Produced In Chinese Hamster Ovary (Cho) K1Sv Cells, Glycoform Alfa (this asset) | Teva Branded Pharmaceutical Products R&D LLC | P1/2 | D · 26 |
| Vincristine Sulfate | Roswell Park Cancer Institute | P3 | BBB |
| Hyaluronidase Fihj | Massachusetts General Hospital | P4 | BBB |
| Filanesib | PETHEMA Foundation | P2 | BBB |
| Cyclosporin A | Seoul National University Hospital | P3 | BBB |
| Prednisone | GlaxoSmithKline | P4 | BB |
| Adriamycin | GlaxoSmithKline | P4 | BB |
| Cis-Diamminedichloroplatinum Ii | Janssen Research & Development, LLC | P4 | BB |
| Thalidomide | Institute of Hematology & Blood Diseases Hospital, China | P4 | BB |
+42 more in the Plasma Cell Myeloma cohort
Other indications for Immunoglobulin G4-Kappa, Anti-(Human Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 (Ec:3.2.2.6) (Adprc 1/Cadrp Hydrolase 1, Cell Surface Antigen Cd38)), Humanized Monoclonal Antibody, Fused At Each C-Terminus Of The Heavy Chains (1-447, 1''-447'') To Attenuated Human Interferon .Alpha.-2B (Ifn.Alpha.2B) Variant (K23>R470, T106>A553, A145>D592) (448-612, 448''-612''); Gamma4 Heavy Chain Humanized Fused To Ifn.Alpha.2B (1-612) (Vh (Homo Sapiens Ighv1-69-2*01 (90.7%)-(Ighd)-Ighj4*01 (85.7%)) Cdrimgt (8.8.13) (26-33.51-58.97-109) (1-120)-Homo Sapiens Ighg4*01, G4V5 H P10 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 (231-340), Ch3 (341-445), Chs (446-447))(121-447), Fused To Ifn.Alpha.2B K23>R (470), T106>A (553), A145>D (592) (448-612)),(134-214')-Disulfide With Kappa Light Chain Humanized (1'-214') (V-Kappa (Homo Sapiens Igkv1-33*01 (83.2%)-Igkj4*01 (100%)) Cdr-Imgt (6.3.9) (27-32.50-52.89-97) (1'-107')-Homo Sapiens Igkc*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')); Dimer (226-226'':229-229'')-Bisdisulfide; Produced In Chinese Hamster Ovary (Cho) K1Sv Cells, Glycoform Alfa
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin G4-Kappa, Anti-(Human Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 (Ec:3.2.2.6) (Adprc 1/Cadrp Hydrolase 1, Cell Surface Antigen Cd38)), Humanized Monoclonal Antibody, Fused At Each C-Terminus Of The Heavy Chains (1-447, 1''-447'') To Attenuated Human Interferon .Alpha.-2B (Ifn.Alpha.2B) Variant (K23>R470, T106>A553, A145>D592) (448-612, 448''-612''); Gamma4 Heavy Chain Humanized Fused To Ifn.Alpha.2B (1-612) (Vh (Homo Sapiens Ighv1-69-2*01 (90.7%)-(Ighd)-Ighj4*01 (85.7%)) Cdrimgt (8.8.13) (26-33.51-58.97-109) (1-120)-Homo Sapiens Ighg4*01, G4V5 H P10 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 (231-340), Ch3 (341-445), Chs (446-447))(121-447), Fused To Ifn.Alpha.2B K23>R (470), T106>A (553), A145>D (592) (448-612)),(134-214')-Disulfide With Kappa Light Chain Humanized (1'-214') (V-Kappa (Homo Sapiens Igkv1-33*01 (83.2%)-Igkj4*01 (100%)) Cdr-Imgt (6.3.9) (27-32.50-52.89-97) (1'-107')-Homo Sapiens Igkc*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')); Dimer (226-226'':229-229'')-Bisdisulfide; Produced In Chinese Hamster Ovary (Cho) K1Sv Cells, Glycoform Alfa in Plasma Cell Myeloma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-g4-kappa-anti-human-adp-ribosyl-cyclasecyclic-adp-ribose-hydrolase-1-ec3226-adprc-1cadrp-hydrolase-1-cell-surface-antigen-cd38-humanized-monoclonal-antibody-fused-at-each-c-terminus-of-the-heavy-chains-1-447-1-447-to-attenuated-human-interferon-alpha-2b-ifnalpha2b-variant-k23r470-t106a553-a145d592-448-612-448-612-gamma4-heavy-chain-humanized-fused-to-ifnalpha2b-1-612-vh-homo-sapiens-ighv1-69-201-907-ighd-ighj401-857-cdrimgt-8813-26-3351-5897-109-1-120-homo-sapiens-ighg401-g4v5-h-p10-ch1-121-218-hinge-1-12-s10p-228-219-230-ch2-231-340-ch3-341-445-chs-446-447121-447-fused-to-ifnalpha2b-k23r-470-t106a-553-a145d-592-448-612134-214-disulfide-with-kappa-light-chain-humanized-1-214-v-kappa-homo-sapiens-igkv1-3301-832-igkj401-100-cdr-imgt-639-27-3250-5289-97-1-107-homo-sapiens-igkc01-100-km3-a451-153-v101-191-108-214-dimer-226-226229-229-bisdisulfide-produced-in-chinese-hamster-ovary-cho-k1sv-cells-glycoform-alfa-plasma-cell-myeloma
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