Immunoglobulin (H-Gamma1_L-Kappa)_Scfvkh-G1(H-Ch2-Ch3), Anti-[Homo Sapiens Klk2 (Kallikrein-2, Kallikrein Related Peptidase 2, Kallikrein 2 Prostatic) And Anti-[Homo Sapiens Cd3E (Cd3 Epsilon, Leu-4)], Homo Sapiens And Humanized Monoclonal Antibody, Bispecific, Bivalent
Adenocarcinoma
Explore 27 assets in Adenocarcinoma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Janssen Research & Development, LLC
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04644770CT.gov A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Adenocarcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Immunoglobulin (H-Gamma1_L-Kappa)_Scfvkh-G1(H-Ch2-Ch3), Anti-[Homo Sapiens Klk2 (Kallikrein-2, Kallikrein Related Peptidase 2, Kallikrein 2 Prostatic) And Anti-[Homo Sapiens Cd3E (Cd3 Epsilon, Leu-4)], Homo Sapiens And Humanized Monoclonal Antibody, Bispecific, Bivalent (this asset) | Janssen Research & Development, LLC | P1 | CC · 43 |
| Cis-Diamminedichloroplatinum Ii | Mayo Clinic | P4 | BBB |
| Carboplatin | Blueprint Medicines Corporation | P4 | BBB |
| Irinotecan | University of Chicago | P2 | BBB |
| Cyclophosphamide | M.D. Anderson Cancer Center | P3 | BB |
| Icotinib | Betta Pharmaceuticals Co., Ltd. | P4 | BB |
| Desflurane | University of Zurich | P4 | BB |
| Fluorouracilum | University of Chicago | P2 | BB |
| Crizotinib | University of Birmingham | P2 | BB |
+42 more in the Adenocarcinoma cohort
Other indications for Immunoglobulin (H-Gamma1_L-Kappa)_Scfvkh-G1(H-Ch2-Ch3), Anti-[Homo Sapiens Klk2 (Kallikrein-2, Kallikrein Related Peptidase 2, Kallikrein 2 Prostatic) And Anti-[Homo Sapiens Cd3E (Cd3 Epsilon, Leu-4)], Homo Sapiens And Humanized Monoclonal Antibody, Bispecific, Bivalent
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Castration-Resistant Prostate Carcinoma | — | P3 | BB · 66 |
| Prostate Cancer | — | P1 | CC · 43 |
| Prostate Neoplasm | — | P1 | C · 39 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Immunoglobulin (H-Gamma1_L-Kappa)_Scfvkh-G1(H-Ch2-Ch3), Anti-[Homo Sapiens Klk2 (Kallikrein-2, Kallikrein Related Peptidase 2, Kallikrein 2 Prostatic) And Anti-[Homo Sapiens Cd3E (Cd3 Epsilon, Leu-4)], Homo Sapiens And Humanized Monoclonal Antibody, Bispecific, Bivalent in Adenocarcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-h-gamma1-l-kappa-scfvkh-g1h-ch2-ch3-anti-homo-sapiens-klk2-kallikrein-2-kallikrein-related-peptidase-2-kallikrein-2-prostatic-and-anti-homo-sapiens-cd3e-cd3-epsilon-leu-4-homo-sapiens-and-humanized-monoclonal-antibody-bispecific-bivalent-adenocarcinoma
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