Izuralimab
Undifferentiated Pleomorphic Sarcoma
Explore 5 assets in Undifferentiated Pleomorphic Sarcoma →Floatz Rating
CC46/100
Confidence
Indicative
Sponsor
Xencor, Inc.
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03752398CT.gov A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Undifferentiated Pleomorphic Sarcoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Izuralimab (this asset) | Xencor, Inc. | P1 | CC · 46 |
| Sorafenib | National Cancer Institute (NCI) | P2 | B |
| Vismodegib | National Cancer Institute (NCI) | P1/2 | CCC |
| Cab-Axl-Adc | BioAtla, Inc. | P1/2 | CCC |
| Ipilimumab | Xencor, Inc. | P1 | CC |
| Samrotamab Vedotin | AbbVie | P1 | CC |
| okn4395 | Epkin | P1 | CC |
| ly3435151 | Eli Lilly and Company | P1 | CC |
| Bbi-355 | Boundless Bio, Inc. | P1 | CC |
+4 more in the Undifferentiated Pleomorphic Sarcoma cohort
Other indications for Izuralimab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Triple-Negative Breast Carcinoma | — | P1 | CC · 47 |
| Cutaneous Melanoma | — | P1 | CC · 47 |
| Head And Neck Squamous Cell Carcinoma | — | P1 | CC · 47 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Izuralimab in Undifferentiated Pleomorphic Sarcoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/immunoglobulin-half-ig-g1-kappascfv-h-ch2-ch3-anti-homo-sapiens-icos-inducible-t-cell-costimulatory-activation-inducible-lymphocyte-immunomediatory-molecule-ailim-cd278-and-anti-homo-sapiens-pdcd1-programmed-cell-death-1-pd-1-pd1-cd279-monoclonal-antibody-bispecific-undifferentiated-pleomorphic-sarcoma
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