Floatz Rating
D30/100
Confidence
Indicative
Sponsor
Abramson Cancer Center at Penn Medicine
Modality
UNKNOWN
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
19High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06337162CT.gov Pre-Transplant INCBB099280 for Hepatocellular Carcinoma (HCC) | — | Withdrawn | — | — | — |
NCT05909995CT.gov Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors | — | Terminated | — | — | — |
NCT04242199CT.gov Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hepatocellular Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Incb099280 (this asset) | Abramson Cancer Center at Penn Medicine | P1 | D · 30 |
| Adriamycin | VA Office of Research and Development | P4 | BBB |
| Fluorouracilum | Li Qiang | P4 | BBB |
| Oxaliplatin | Li Qiang | P4 | BBB |
| Theprubicin | RWTH Aachen University | P4 | BBB |
| Iodized Ethyl Esters Of Poppyseed Fatty Acids | RWTH Aachen University | P4 | BBB |
| Lenvatinib | Zhejiang Haichang Biotech Co., Ltd. | P4 | BB |
| Epirubicin | Fudan University | P4 | BB |
| Adefovir | Bukwang Pharmaceutical | P4 | BB |
+42 more in the Hepatocellular Carcinoma cohort
Other indications for Incb099280
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cancer | — | P2 | C · 38 |
| Cutaneous Neuroendocrine Carcinoma | — | P1 | C · 34 |
| Skin Squamous Cell Carcinoma | — | P1 | C · 34 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Incb099280 in Hepatocellular Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/incb099280-hepatocellular-carcinoma
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