Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
The George Institute
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
53High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03785067CT.gov Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study | — | Terminated | — | — | — |
NCT03626506CT.gov Spironolactone Versus Indapamide in Obese and Hypertensive Patients | — | Unknown | — | — | — |
NCT03783754CT.gov Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Magnetic Resonance Imaging Sub-study | — | Terminated | — | — | — |
NCT02699645CT.gov Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial | — | Completed | — | — | — |
NCT00122811CT.gov The Hypertension in the Very Elderly Trial (HYVET) | — | Unknown | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hypertensive Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Indapamide (this asset) | The George Institute | Approved | BB · 64 |
| Valsartan | University of Alabama at Birmingham | P4 | BBB |
| Hydrochlorothiazide | University of Kansas Medical Center | P4 | BBB |
| Losartan | Rong Zhang | P4 | BBB |
| Amlodipine | Jing Liu | P4 | BBB |
| Trandolapril | University of Florida | P4 | BBB |
| Olmesartan Medoxomil | Virginia Polytechnic Institute and State University | P4 | BBB |
| Corpril | University of Michigan | P4 | BBB |
| Cilnidipine | Boryung Pharmaceutical Co., Ltd | P4 | BBB |
+42 more in the Hypertensive Disorder cohort
Other indications for Indapamide
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hemorrhagic Stroke | — | P3 | B · 58 |
| Intracerebral Hemorrhage | — | P3 | B · 58 |
| Vascular Dementia | — | P3 | B · 58 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Indapamide in Hypertensive Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/indapamide-hypertensive-disorder
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