Floatz Rating
CC47/100
Confidence
Indicative
Sponsor
Ionis Pharmaceuticals, Inc.
Modality
UNKNOWN
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07531745CT.gov ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Dravet Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| ion337 (this asset) | Ionis Pharmaceuticals, Inc. | P1/2 | CC · 47 |
| Benzeneethanamine, N-Ethyl-?-Methyl-4-(Trifluoromethyl)-, Hydrochloride, (±)- | The University of Texas Health Science Center, Houston | P4 | BBB |
| Bexicaserin | Longboard Pharmaceuticals | P3 | BB |
| Rna, (P-Thio)[2?-O-(2-Methoxyethyl)](A-G-M?U-M?U-G-G-A-G-M?C-A-A-G-A-M?U-M?U-A-M?U-M?C) | Stoke Therapeutics, Inc | P3 | BB |
| gwp42003-p | Jazz Pharmaceuticals | P3 | BB |
| Clemizole | Epygenix | P3 | BB |
| Soticlestat | Takeda | P3 | B |
| Clobazam | H. Lundbeck A/S | P3 | B |
| Verapamil Slow Release | Gillette Children's Specialty Healthcare | P2 | B |
+7 more in the Dravet Syndrome cohort
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- Benzeneethanamine, N-Ethyl-?-Methyl-4-(Trifluoromethyl)-, Hydrochloride, (±)-The University of Texas Health Science Center, HoustonBBB
- BexicaserinLongboard PharmaceuticalsBB
- Rna, (P-Thio)[2?-O-(2-Methoxyethyl)](A-G-M?U-M?U-G-G-A-G-M?C-A-A-G-A-M?U-M?U-A-M?U-M?C)Stoke Therapeutics, IncBB
- gwp42003-pJazz PharmaceuticalsBB
- ClemizoleEpygenixBB
Citation
Floatz Terminal. ion337 in Dravet Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/ion337-dravet-syndrome
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