Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
Inge Marie Svane
Modality
monoclonal_antibody
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
56High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07501117CT.gov Neoadjuvant Immunotherapy for Patients With High-risk Eye Melanoma | — | Not Yet Recruiting | — | — | — |
NCT06581406CT.gov A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma | — | Recruiting | — | — | — |
NCT06784648CT.gov Different Doses of BI-1607 in Combination With Pembrolizumab and Ipilimumab, in Participants With Unresectable or Metastatic Melanoma | — | Active Not Recruiting | — | — | — |
NCT06519266CT.gov PHP in Combination With IPI1/NIVO3 Compared to IPI3/NIVO1 Only in Patients With Uveal Melanoma Liver Metastases | — | Recruiting | — | — | — |
NCT05987332CT.gov IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma | — | Active Not Recruiting | — | — | — |
NCT05341349CT.gov Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases | — | Terminated | — | — | — |
NCT05004025CT.gov Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma | — | Completed | — | — | — |
NCT04935229CT.gov Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma | — | Terminated | — | — | — |
NCT04463368CT.gov Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metastases | — | Completed | — | — | — |
NCT04283890CT.gov PHP and Immunotherapy in Metastasized UM | — | Active Not Recruiting | — | — | — |
Show 16 more trialsShow fewer
NCT03922880CT.gov Study of Immunotherapy Plus ADI-PEG 20 for the Treatment of Advanced Uveal Melanoma | — | Completed | — | — | — |
NCT03472586CT.gov Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver | — | Completed | — | — | — |
NCT03326258CT.gov Glembatumumab Vedotin, Nivolumab, and Ipilimumab in Treating Patients With Advanced Metastatic Solid Tumors That Cannot Be Removed by Surgery | — | Withdrawn | — | — | — |
NCT03408587CT.gov CAVATAK® and Ipilimumab in Uveal Melanoma Metastatic to the Liver (VLA-024 CLEVER) | — | Completed | — | — | — |
NCT03070392CT.gov Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma | — | Completed | — | — | — |
NCT03068624CT.gov Autologous CD8+ SLC45A2-Specific T Lymphocytes With Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Uveal Melanoma | — | Unknown | — | — | — |
NCT02913417CT.gov Yttrium90, Ipilimumab, & Nivolumab for Uveal Melanoma With Liver Metastases | — | Unknown | — | — | — |
NCT02626962CT.gov Trial of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated Metastatic Uveal Melanoma | — | Completed | — | — | — |
NCT02519322CT.gov Neoadjuvant and Adjuvant Checkpoint Blockade | — | Completed | — | — | — |
NCT02158520CT.gov Nab-Paclitaxel and Bevacizumab or Ipilimumab as First-Line Therapy in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery | — | Completed | — | — | — |
NCT01730157CT.gov Radioembolization and Ipilimumab in Treating Patients With Uveal Melanoma With Liver Metastases | — | Terminated | — | — | — |
NCT01585194CT.gov Nivolumab and Ipilimumab in Treating Patients With Metastatic Uveal Melanoma | — | Completed | — | — | — |
NCT00084656CT.gov Monoclonal Antibody Therapy and Vaccine Therapy in Treating Patients With Resected Stage III or Stage IV Melanoma | — | Completed | — | — | — |
NCT00058279CT.gov Monoclonal Antibody Therapy and Interleukin-2 in Treating Patients With Metastatic Melanoma | — | Completed | — | — | — |
NCT00032045CT.gov Vaccine Therapy and Monoclonal Antibody Therapy in Treating Patients With Stage IV Melanoma | — | Completed | — | — | — |
NCT00025181CT.gov Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Uveal Melanoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Ipilimumab (this asset) | Inge Marie Svane | P3 | BB · 64 |
| Ifa | Craig L Slingluff, Jr | P2 | BBB |
| Tyrosinase Peptide | University of Southern California | P3 | BB |
| Sargramostim | Thomas Jefferson University | P3 | BB |
| Cyclophosphamide | Beijing Biotech | P2/3 | BB |
| Darovasertib | IDEAYA Biosciences | P3 | BB |
| Gm-Csf | Ahmad Tarhini | P2 | BB |
| Pembrolizumab | BioInvent International AB | P2/3 | BB |
| Thalidomide | Memorial Sloan Kettering Cancer Center | P2 | BB |
+42 more in the Uveal Melanoma cohort
Other indications for Ipilimumab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Metastatic Neoplasm | — | P3 | BB · 71 |
| Melanoma | — | P4 | BB · 69 |
| Cutaneous Melanoma | — | P3 | BB · 69 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Ipilimumab in Uveal Melanoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/ipilimumab-uveal-melanoma
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