Irinotecan
Carcinoma Of Liver And Intrahepatic Biliary Tract
Explore 3 assets in Carcinoma Of Liver And Intrahepatic Biliary Tract →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
OHSU Knight Cancer Institute
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04251715CT.gov mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Carcinoma Of Liver And Intrahepatic Biliary Tract
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Irinotecan (this asset) | OHSU Knight Cancer Institute | P2 | CCC · 53 |
| Selumetinib | National Cancer Institute (NCI) | P2 | B |
| Immunoglobulin G1, Anti-(Human Vascular Endothelial Growth Factor Receptor Type Vegfr-2 Extracellular Domain) (Human Monoclonal Imc-1121B .Gamma.-Chain), Disulphide With Human Monoclonal Imc-1121B .Kappa.-Chain, Dimer | M.D. Anderson Cancer Center | P2 | B |
| Dexasone | OHSU Knight Cancer Institute | P2 | CCC |
| Floxuridine | OHSU Knight Cancer Institute | P2 | CCC |
| Oxaliplatin | OHSU Knight Cancer Institute | P2 | CCC |
| Umbilical Cord Blood Derived Mak Immune Cells | Zhou Fuxiang | P1 | CC |
| Anti-Gpc3 Car-T Cells | Beijing Immunochina Medical Science & Technology Co., Ltd. | Early P1 | C |
| Soluble Fluorescein | Mayo Clinic | N/A | D |
+1 more in the Carcinoma Of Liver And Intrahepatic Biliary Tract cohort
Other indications for Irinotecan
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Rectal Cancer | — | P4 | BBB · 78 |
| Exocrine Pancreatic Carcinoma | — | P2/3 | BBB · 78 |
| Colon Adenocarcinoma | — | P3 | BBB · 76 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- SelumetinibNational Cancer Institute (NCI)B
- Immunoglobulin G1, Anti-(Human Vascular Endothelial Growth Factor Receptor Type Vegfr-2 Extracellular Domain) (Human Monoclonal Imc-1121B .Gamma.-Chain), Disulphide With Human Monoclonal Imc-1121B .Kappa.-Chain, DimerM.D. Anderson Cancer CenterB
- DexasoneOHSU Knight Cancer InstituteCCC
- FloxuridineOHSU Knight Cancer InstituteCCC
- OxaliplatinOHSU Knight Cancer InstituteCCC
Citation
Floatz Terminal. Irinotecan in Carcinoma Of Liver And Intrahepatic Biliary Tract. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/irinotecan-carcinoma-of-liver-and-intrahepatic-biliary-tract
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