Ivosidenib
Myelodysplastic Syndrome With Excess Blasts-2
Explore 16 assets in Myelodysplastic Syndrome With Excess Blasts-2 →Floatz Rating
B60/100
Confidence
Indicative
Sponsor
Stichting Hemato-Oncologie voor Volwassenen Nederland
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
45Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03839771CT.gov A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Myelodysplastic Syndrome With Excess Blasts-2
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Ivosidenib (this asset) | Stichting Hemato-Oncologie voor Volwassenen Nederland | P3 | B · 60 |
| Fludarabine | Sumithira Vasu | P2 | BB |
| Gilteritinib | Stichting Hemato-Oncologie voor Volwassenen Nederland | P3 | BB |
| Cytarabine | Sumithira Vasu | P2 | BB |
| Midostaurin | Stichting Hemato-Oncologie voor Volwassenen Nederland | P3 | B |
| Azacitidine | Aptose Biosciences Inc. | P2 | B |
| Cyclophosphamide | Fred Hutchinson Cancer Center | P2 | B |
| Thiotepa | Fred Hutchinson Cancer Center | P2 | B |
| Tacrolimus | Fred Hutchinson Cancer Center | P2 | B |
+20 more in the Myelodysplastic Syndrome With Excess Blasts-2 cohort
Other indications for Ivosidenib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Acute Myeloid Leukemia With Multilineage Dysplasia | — | P3 | BB · 66 |
| Myeloproliferative Neoplasm | — | P2 | B · 62 |
| Acute Myeloid Leukemia | — | P3 | B · 61 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Ivosidenib in Myelodysplastic Syndrome With Excess Blasts-2. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/ivosidenib-myelodysplastic-syndrome-with-excess-blasts-2
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