Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
University of Pennsylvania
Modality
Small molecule
Development Phase
Early Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
No trial-level evidence is linked to this axis yet.
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Opiate Dependence
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Izaflortaucipir (this asset) | University of Pennsylvania | Early P1 | CC · 43 |
| Buprenorphine | Erin Winstanley | P4 | BBB |
| Lidocaine | University Medical Centre Ljubljana | P4 | BB |
| 17-ALLYL-4,5A-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE | University of California, San Francisco | P4 | BB |
| Marcaine | Denver Health and Hospital Authority | P4 | BB |
| Gabapentin | Brigham and Women's Hospital | P4 | BB |
| Epclusa | Saskatchewan Health Authority - Regina Area | P4 | BB |
| Sufentanyl | West Virginia University | P4 | BB |
| Biktarvy | Saskatchewan Health Authority - Regina Area | P4 | BB |
+20 more in the Opiate Dependence cohort
Other indications for Izaflortaucipir
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Alzheimer Disease | — | P3 | BB · 65 |
| Frontotemporal Dementia | — | P3 | BB · 64 |
| Parkinson Disease | — | P2 | CCC · 55 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Izaflortaucipir in Opiate Dependence. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/izaflortaucipir-opiate-dependence
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