Floatz Rating
CC47/100
Confidence
Indicative
Sponsor
Kymera Therapeutics, Inc.
Modality
UNKNOWN
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05775406CT.gov Safety and Clinical Activity of KT-253 in Adult Patients with High Grade Myeloid Malignancies, Acute Lymphocytic Leukemia, Lymphoma, Solid Tumors | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Myeloid Neoplasm
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| kt-253 (this asset) | Kymera Therapeutics, Inc. | P1 | CC · 47 |
| Cytarabine | First Affiliated Hospital of Zhejiang University | P3 | BBB |
| Mitoxantrone | First Affiliated Hospital of Zhejiang University | P3 | BBB |
| Cladribine | University of Washington | P2 | BBB |
| Cyclophosphamide | Prelude Therapeutics | P3 | BB |
| Venetoclax | First Affiliated Hospital of Zhejiang University | P3 | BB |
| Recombinant Human Granulocyte Colony-Stimulating Factor | University of Washington | P2 | BB |
| Idarubicin | Northwestern University | P3 | BB |
| Fludarabine | First Affiliated Hospital of Zhejiang University | P3 | BB |
+38 more in the Myeloid Neoplasm cohort
Other indications for kt-253
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Lymphoma | — | P1 | CC · 47 |
| Acute Lymphoblastic Leukemia | — | P1 | CC · 46 |
| Cancer | — | P1 | C · 39 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. kt-253 in Myeloid Neoplasm. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/kt-253-myeloid-neoplasm
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