L-Prolinamide, N-(19-Carboxy-1-Oxononadecyl)-L-?-Glutamyl-L-Arginyl-L-?-Aspartylglycyl-L-Threonyl-L-Alanyl-L-Threonyl-L-Lysyl-L-Alanyl-L-Threonyl-L-?-Glutamyl-L-Arginyl-L-Leucyl-L-Alanyl-5-Carboxy-L-Norvalyl-L-Phenylalanyl-L-Leucyl-L-Glutaminyl-L-Arginyl-L-Seryl-L-Seryl-L-Phenylalanyl-N-Methylglycyl-L-Alanyl-N-Methyl-L-Isoleucyl-L-Leucyl-L-Seryl-L-Seryl-L-Threonyl-L-?-Glutamyl-L-Valylglycyl-L-Seryl-L-Asparaginyl-L-Threonyl-4-Hydroxy-, (3?8)-Lactam, (4R)-
Type 2 Diabetes Mellitus
Explore 135 assets in Type 2 Diabetes Mellitus →Floatz Rating
CCC51/100
Confidence
Indicative
Sponsor
Zealand Pharma
Modality
protein_peptide
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06926842CT.gov Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2) | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Type 2 Diabetes Mellitus
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| L-Prolinamide, N-(19-Carboxy-1-Oxononadecyl)-L-?-Glutamyl-L-Arginyl-L-?-Aspartylglycyl-L-Threonyl-L-Alanyl-L-Threonyl-L-Lysyl-L-Alanyl-L-Threonyl-L-?-Glutamyl-L-Arginyl-L-Leucyl-L-Alanyl-5-Carboxy-L-Norvalyl-L-Phenylalanyl-L-Leucyl-L-Glutaminyl-L-Arginyl-L-Seryl-L-Seryl-L-Phenylalanyl-N-Methylglycyl-L-Alanyl-N-Methyl-L-Isoleucyl-L-Leucyl-L-Seryl-L-Seryl-L-Threonyl-L-?-Glutamyl-L-Valylglycyl-L-Seryl-L-Asparaginyl-L-Threonyl-4-Hydroxy-, (3?8)-Lactam, (4R)- (this asset) | Zealand Pharma | P2 | CCC · 51 |
| Liraglutide | RenJi Hospital | P4 | BBB |
| Semaglutide | Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Exenatide | Vivani Medical, Inc | P4 | BBB |
| Cotadutide | AstraZeneca | P2 | BBB |
| Dapagliflozin | Bhavya Bhavya, MD | P4 | BBB |
| Metformin | Myopharm Limited | P4 | BBB |
| Saxagliptin | Nick Giannoukakis, PhD | P4 | BBB |
| Pioglitazone | Seoul National University Bundang Hospital | P4 | BBB |
+41 more in the Type 2 Diabetes Mellitus cohort
Other indications for L-Prolinamide, N-(19-Carboxy-1-Oxononadecyl)-L-?-Glutamyl-L-Arginyl-L-?-Aspartylglycyl-L-Threonyl-L-Alanyl-L-Threonyl-L-Lysyl-L-Alanyl-L-Threonyl-L-?-Glutamyl-L-Arginyl-L-Leucyl-L-Alanyl-5-Carboxy-L-Norvalyl-L-Phenylalanyl-L-Leucyl-L-Glutaminyl-L-Arginyl-L-Seryl-L-Seryl-L-Phenylalanyl-N-Methylglycyl-L-Alanyl-N-Methyl-L-Isoleucyl-L-Leucyl-L-Seryl-L-Seryl-L-Threonyl-L-?-Glutamyl-L-Valylglycyl-L-Seryl-L-Asparaginyl-L-Threonyl-4-Hydroxy-, (3?8)-Lactam, (4R)-
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Obesity Disorder | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. L-Prolinamide, N-(19-Carboxy-1-Oxononadecyl)-L-?-Glutamyl-L-Arginyl-L-?-Aspartylglycyl-L-Threonyl-L-Alanyl-L-Threonyl-L-Lysyl-L-Alanyl-L-Threonyl-L-?-Glutamyl-L-Arginyl-L-Leucyl-L-Alanyl-5-Carboxy-L-Norvalyl-L-Phenylalanyl-L-Leucyl-L-Glutaminyl-L-Arginyl-L-Seryl-L-Seryl-L-Phenylalanyl-N-Methylglycyl-L-Alanyl-N-Methyl-L-Isoleucyl-L-Leucyl-L-Seryl-L-Seryl-L-Threonyl-L-?-Glutamyl-L-Valylglycyl-L-Seryl-L-Asparaginyl-L-Threonyl-4-Hydroxy-, (3?8)-Lactam, (4R)- in Type 2 Diabetes Mellitus. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/l-prolinamide-n-19-carboxy-1-oxononadecyl-l-glutamyl-l-arginyl-l-aspartylglycyl-l-threonyl-l-alanyl-l-threonyl-l-lysyl-l-alanyl-l-threonyl-l-glutamyl-l-arginyl-l-leucyl-l-alanyl-5-carboxy-l-norvalyl-l-phenylalanyl-l-leucyl-l-glutaminyl-l-arginyl-l-seryl-l-seryl-l-phenylalanyl-n-methylglycyl-l-alanyl-n-methyl-l-isoleucyl-l-leucyl-l-seryl-l-seryl-l-threonyl-l-glutamyl-l-valylglycyl-l-seryl-l-asparaginyl-l-threonyl-4-hydroxy-38-lactam-4r-type-2-diabetes-mellitus
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