Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Children's Oncology Group
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03834961CT.gov Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Cancer Or Benign Tumor
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Larotrectinib (this asset) | Children's Oncology Group | P2 | CCC · 53 |
| Memantine | NRG Oncology | P3 | BB |
| Cis-Diamminedichloroplatinum Ii | Emory University | P1 | CCC |
| Cabozantinib | National Cancer Institute (NCI) | P2 | CCC |
| Carboplatin | Emory University | P1 | CCC |
| Veliparib | National Cancer Institute (NCI) | P1 | CCC |
| Ilorasertib | University of Chicago | P1 | CC |
| 2 (1H))-QUINOLINONE,6-(AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-4-(3-CHLOROPHENYL)-1-METHYL-,(+)- | National Cancer Institute (NCI) | P1 | CC |
| Muamycin | National Cancer Institute (NCI) | P1 | CC |
+16 more in the Cancer Or Benign Tumor cohort
Other indications for Larotrectinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| NTRK Fusion Positive Cancer | — | P1/2 | BB · 65 |
| Non-Hodgkin Lymphoma | — | P2 | CCC · 53 |
| Refractory Malignant Neoplasm | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Larotrectinib in Cancer Or Benign Tumor. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/larotrectinib-cancer-or-benign-tumor
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