Floatz Rating
BB67/100
Confidence
Indicative
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
63High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06726421CT.gov Systemic Therapy Alone or With Stereotactic Body Radiotherapy for Oligometastatic Kidney Cancer (STROKER Study) | — | Recruiting | — | — | — |
NCT06364631CT.gov CARE1 Pragmatic Clinical Trial | — | Recruiting | — | — | — |
NCT05485883CT.gov Tislelizumab Plus Lenvatinib in Stage III-IV RCC | — | Unknown | — | — | — |
NCT04393350CT.gov Perioperative Lenvatinib With Pembrolizumab in Patients With Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma | — | Active Not Recruiting | — | — | — |
NCT00747305CT.gov Sunitinib Before and After Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed By Surgery | — | Terminated | — | — | — |
NCT00717587CT.gov Sunitinib Before and After Surgery in Treating Patients With Stage IV Kidney Cancer | — | Unknown | — | — | — |
NCT00626509CT.gov Sunitinib Before or After Surgery in Treating Patients With Metastatic Kidney Cancer | — | Unknown | — | — | — |
NCT01024205CT.gov Sunitinib Malate Before and After Surgery in Treating Patients With Previously Untreated Metastatic Kidney Cancer | — | Completed | — | — | — |
NCT00849186CT.gov Sunitinib and Surgery in Treating Patients With Localized or Metastatic Kidney Cancer | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Kidney Cancer
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Lenvatinib (this asset) | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Approved | BB · 67 |
| Alpha-Interferon | Dartmouth-Hitchcock Medical Center | P3 | BBB |
| Girentuximab | Memorial Sloan Kettering Cancer Center | P3 | BB |
| Nivestim | National Institutes of Health Clinical Center (CC) | P3 | BB |
| Etoposide | City of Hope Medical Center | P3 | BB |
| Fluorouracilum | Medical Research Council | P3 | BB |
| Isocyclophosphamide | City of Hope Medical Center | P3 | BB |
| Sargramostim | Barbara Ann Karmanos Cancer Institute | P2 | BB |
| Cyclophosphamide | Oliver Jonas | P3 | BB |
+42 more in the Kidney Cancer cohort
Other indications for Lenvatinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Portal Vein Thrombosis | — | P4 | BBB · 73 |
| Ovarian Carcinoma | — | P4 | BB · 70 |
| Hepatocellular Carcinoma | — | P4 | BB · 69 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Lenvatinib in Kidney Cancer. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/lenvatinib-kidney-cancer
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