Floatz logo
Floatz Rating
BB67/100
Confidence
Indicative
v0.2
Sponsor
Mayo Clinic
Modality
protein_peptide
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
73High confidence
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial
Not Yet Recruiting
Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer
Recruiting
A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer.
Recruiting
Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT
Recruiting
Study of Recurrence-directed Therapy (RDT) With or Without Androgen-Deprivation Therapy (ADT) In Patients With Radio-recurrent Oligo-metastatic Hormone/Castrate Sensitive Prostate Cancer (romCSPC)
Recruiting
A Study to Learn How Men With Advanced Prostate Cancer Respond to Treatment With Darolutamide and Hormone Therapy, With or Without Chemotherapy, in Real-world Medical Practice
Active Not Recruiting
Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)
Recruiting
Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer
Recruiting
COACTION Trial - COmbination Androgen bloCkade in inTermediate to hIgh-risk prOstate caNcer
Active Not Recruiting
Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer
Recruiting
Show 122 more trials
Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial
Recruiting
ADT and SBRT vs SBRT Alone for Unfavorable Intermediate Risk Prostate Cancer
Recruiting
A Neoadjuvant Study of Abiraterone Acetate, Leuprolide Acetate, and Belzutifan in Men With Regional Prostate Cancer
Withdrawn
Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular Tracers
Recruiting
Neo-DAB: Darolutamide and Abemaciclib in Prostate Cancer
Completed
A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies
Active Not Recruiting
Short Versus Long-term Androgen Deprivation Therapy With Salvage Radiotherapy in Prostate Cancer. URONCOR 0624
Recruiting
EvaluatioN of HIFU Hemiablation and Short Term AndrogeN Deprivation Therapy Combination to Enhance Prostate Cancer Control.
Unknown
The Study Will Evaluate if Leuprolide Mesylate is Safe and Effective in the Treatment of Subjects With Advanced Prostate Carcinoma, When Administered as Two Injections Six Months Apart.
Completed
Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer
Unknown
A Study to Learn How Well Darolutamide Administered Together With Androgen Deprivation Therapy (ADT) Works in Men With Metastatic Hormone-sensitive Prostate Cancer. Results Will be Compared With ADT Alone From a Previously Conducted Study.
Active Not Recruiting
A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy
Active Not Recruiting
Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer
Recruiting
Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer
Active Not Recruiting
To Compare the Safety and Pharmacokinetics of PT105 With PT105R in Healthy Postmenopausal Female Volunteers
Unknown
Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
Active Not Recruiting
Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the Treatment of Biochemically Recurrent Prostate Cancer, RESTART Study
Withdrawn
A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer
Active Not Recruiting
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
Recruiting
Androgen Deprivation Therapy for Oligo-recurrent Prostate Cancer in Addition to radioTherapy
Active Not Recruiting
Neoadjuvant Intense Endocrine Therapy for High Risk and Locally Advanced Prostate Cancer
Recruiting
Prediction of the PRONOUNCE Prostate Cancer Trial in Healthcare Claims Data
Completed
Postop Hypofractionated Radiation Therapy and LHRH in Patients With Prostate Cancer
Recruiting
Effects of Muscadine Grape Extract in Men With Prostate Cancer on Androgen Deprivation Therapy
Completed
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
Recruiting
Intermittent Androgen Deprivation Therapy for Stage IV Castration Sensitive Prostate Cancer
Active Not Recruiting
A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local Treatment
Completed
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
Unknown
Systemic and Tumor-Directed Therapy for Oligometastatic Prostate Cancer
Completed
A Salvage Trial of AR Inhibition With ADT and Apalutamide With Radiation Therapy Followed by Docetaxel in Men With PSA Recurrent Prostate Cancer After Radical Prostatectomy (STARTAR)
Completed
Study of Abiraterone Acetate Plus ADT Versus APALUTAMIDE Versus Abiraterone and APALUTAMIDE in Patients With Advanced Prostate Cancer With Non-castrate Testosterone Levels
Completed
A Study of Docetaxel + ARN-509 in Castration-Resistant Prostate Cancer
Terminated
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
Recruiting
Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prostatectomy
Completed
Apalutamide and Leuprolide in Intermediate and High-risk Prostate Cancer
Completed
Anti-Androgens and Cabazitaxel in Defining Complete Response in Prostatectomy (ACDC Trial)
Completed
AASUR in High Risk Prostate Cancer
Completed
A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease
Terminated
Special Drug Use Surveillance of Leuplin PRO for Injection Kit 22.5 mg for "Prostate Cancer"
Completed
Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression
Terminated
LEE011 (Ribociclib) in Combination With Docetaxel Plus Prednisone in mCRPC
Completed
Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer
Completed
Androgen Deprivation Therapy or Androgen Deprivation Therapy Plus Definitive Treatment (Radiation or Surgery)
Unknown
Micro RNAs to Predict Response to Androgen Deprivation Therapy
Completed
High-Dose Brachytherapy in Treating Patients With Prostate Cancer
Active Not Recruiting
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
Active Not Recruiting
Enzalutamide/Leuprolide +/- Abiraterone/Pred in Prostate
Completed
Therapy Pathways in the Treatment of Hormone Naïve Prostate Cancer Patients With and Without Comorbidities Treated With Degarelix or Luteinizing-Hormone-Releasing-Hormone (LHRH) Agonists.
Completed
Phase II Study of Subcutaneous Injection Depot of Leuprolide Acetate in Patient With Prostate Cancer
Completed
Salvage Radiotherapy Combined With Hormonotherapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer
Completed
A Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Prostate Cancer
Completed
LHRH Analogue Therapy With Enzalutamide or Bicalutamide in Treating Patients With Hormone Sensitive Prostate Cancer
Completed
Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer
Completed
Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer
Active Not Recruiting
Salvage Therapeutic Radiation With Enzalutamide and ADT in Men With Recurrent Prostate Cancer (STREAM)
Completed
A Study of the Effect of Enantone LP 11.25 mg (Leuprorelin) on the Histological Progression of Indolent Prostate Cancer
Completed
A Study of Neoadjuvant TAK-700 and Leuprorelin Acetate Followed by Surgery Versus Surgery Alone
Terminated
Bipolar Androgen-based Therapy for Prostate Cancer (BAT)
Completed
Neoadjuvant Chemohormonal Therapy Followed by Salvage Surgery for High Risk PSA
Terminated
Study of Enzalutamide (Formerly MDV3100) as a Neoadjuvant Therapy for Patients Undergoing Prostatectomy for Localized Prostate Cancer
Completed
Phase II Study of DCVAC/PCa Added to Hormone Therapy for Men With Metastatic Prostate Cancer
Completed
A Phase 3 Comparative Study of TAP-144-SR(6M) in Prostate Cancer Patients Previously Treated With Hormonal Therapy
Completed
Sequencing of Sipuleucel-T and ADT in Men With Non-metastatic Prostate Cancer
Completed
Efficacy and Safety of Leuprolide Acetate 22.5 mg Depot in Treatment of Prostate Cancer
Completed
Ipilimumab + Androgen Depravation Therapy in Prostate Cancer
Terminated
Effect of GTx-758 on Total and Free Testosterone Levels in Men With Prostate Cancer
Terminated
Initiation of Androgen Deprivation Therapy for Prostate Cancer Using Degarelix Followed by Leuprolide
Completed
Efficacy and Safety Study of ELIGARD 22.5mg With Prostate Cancer
Completed
Bicalutamide and Goserelin or Leuprolide Acetate With or Without Cixutumumab in Treating Patients With Newly Diagnosed Metastatic Prostate Cancer
Completed
Study in Men With Prostate Cancer to Assess the Safety, Pharmacokinetics and Testosterone-Lowering Efficacy of TAK-448
Terminated
Neoadjuvant Ipilimumab in Prostate Cancer
Completed
Leuprolide Acetate or Goserelin Acetate With or Without Vismodegib Followed by Surgery in Treating Patients With Locally Advanced Prostate Cancer
Terminated
Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration
Completed
Abiraterone Prednisone and Hormonal Therapy Before and During Radiation Therapy in Localized Prostate Cancer
Completed
Leuprolide Acetate or Goserelin Acetate Compared With Observation in Treating Patients With High-Risk Prostate Cancer Who Have Undergone Radical Prostatectomy
Terminated
A Study of Degarelix in Patients With Prostate Cancer
Completed
Neoadjuvant Dasatinib Plus LHRH Analogue Therapy in High-Risk Localized Prostate Cancer
Terminated
Everolimus, Bicalutamide, and Leuprolide Acetate in Treating Patients Undergoing Radiation Therapy For High-Risk Locally Advanced Prostate Cancer
Completed
Lucrin® Depot Efficacy and Safety Monitoring Study in Patients With Advanced Prostate Cancer and Lower Urinary Tract Symptoms (LUTS)
Completed
Safety Study of Sorafenib With Androgen Deprivation and Radiotherapy to Treat Prostate Cancer
Terminated
Androgen Ablation Therapy With or Without Vaccine Therapy in Treating Patients With Prostate Cancer
Withdrawn
Androgen Suppression and Radiation With/Out Docetaxel in High-Risk Localized Prostate Cancer
Terminated
Sunitinib Malate, Hormone Ablation and Radiation Therapy in Patients With Prostate Cancer
Completed
A Study of Leuprolide to Treat Prostate Cancer
Completed
Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer
Completed
RADICALS - Radiotherapy and Androgen Deprivation In Combination After Local Surgery
Completed
Hormone Therapy and Temsirolimus in Treating Patients With Relapsed Prostate Cancer
Terminated
Safety and Efficacy Study of Leuprolide Acetate for Injectable Suspension 22.5 MG in the Treatment of Prostate Cancer
Completed
A Long-term Extension Study Evaluating a One-Month Dosing Regimen of Degarelix in Prostate Cancer Requiring Androgen Ablation Therapy
Completed
Pazopanib Hydrochloride After Leuprolide Acetate or Goserelin Acetate in Treating Patients With Relapsed Prostate Cancer
Completed
A Phase IIIb Study of Intermittent Versus Continuous Hormone Deprivation Treatment With ELIGARD
Completed
The Efficacy and Safety of Degarelix One Month Dosing Regimens in Prostate Cancer
Completed
Leuplin SR 11.25 mg Injection Kit Specified Drug-use Survey "Long-term Use Survey in Prostate Cancer Patients (96 Weeks)"
Completed
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
Active Not Recruiting
Neoadjuvant Hormones + Docetaxel in Node-Positive Prostate Cancer
Completed
External Beam Radiation Therapy (EBRT) With or Without Hormonal Therapy in Prostate Cancer
Terminated
Implant and External Radiation for Prostate Cancer With or Without Hormonal Therapy: A Prospective Randomized Trial
Terminated
Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases
Completed
Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer
Completed
Clinical Trial for Prostate Cancer
Completed
RADAR Trial - Randomised Androgen Deprivation and Radiotherapy
Completed
Evaluate Recovery of Testosterone for Patients Using Eligard
Completed
Docetaxel With Rapid Hormonal Cycling as a Treatment for Patients With Prostate Cancer
Completed
Hormonal Ablation, Imatinib Mesylate and Docetaxel for Patients With Prostate Cancer
Completed
Intensity-Modulated Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Prostate Cancer
Completed
Hormone Therapy With or Without Squalamine Lactate in Treating Patients Who Are Undergoing a Radical Prostatectomy for Locally Advanced Prostate Cancer
Withdrawn
S0032, Combination Chemotherapy Plus Hormone Therapy in Treating Patients With Metastatic Prostate Cancer
Completed
SU5416 Plus Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
Completed
Chemotherapy, Hormone Therapy, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
Completed
Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer
Completed
Leuprorelin Associated With Radiotherapy Versus Leuprorelin Alone in T3 - T4 or pT3 (on Biopsy) N0, M0 Prostate Cancer
Completed
Randomized Trial of Adjuvant Hormonal Therapy in Surgically Treated Prostate Cancer Patients at High Risk for Recurrence
Terminated
Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer
Completed
Combination Chemotherapy in Treating Patients With Advanced Prostate Cancer
Completed
Hormone Therapy Plus Radiation Therapy in Treating Patients With Prostate Cancer
Completed
Radiation Therapy With Androgen Suppression in Treating Patients With Prostate Cancer
Completed
Effects of IAS in Men With Localized Biochemical Relapsed Prostate Cancer
Completed
Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer
Completed
Study of External Beam Radiation Therapy With and Without Hormonal Therapy to Treat Prostate Cancer
Completed
Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer
Completed
Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
Completed
Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer
Withdrawn

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.

Same indication · Prostate Cancer

AssetSponsorPhaseRating
Leuporelin (this asset)Mayo ClinicApprovedBB · 67
AvodartBay State Clinical Trials, Inc.P4BBB
DesfluranePeter MacCallum Cancer Centre, AustraliaP4BBB
PropofolPeter MacCallum Cancer Centre, AustraliaP4BBB
DegarelixBayerP4BBB
Flotufolastat F 18Washington University School of MedicineP4BB
AVOLVEMasonic Cancer Center, University of MinnesotaP4BB
EstramustineThe University of Texas Health Science Center, HoustonP3BB
PasireotideRECORDATI GROUPP4BB

+42 more in the Prostate Cancer cohort

Other indications for Leuporelin

IndicationSponsorPhaseRating
Prostate CarcinomaP4BBB · 74
Metastatic Prostate CarcinomaP4BBB · 72
Prostate NeoplasmP4BB · 71

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Leuporelin in Prostate Cancer. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/leuporelin-prostate-cancer

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