Floatz Rating
CC40/100
Confidence
Indicative
Sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
25Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01051440CT.gov Magnetic Resonance Imaging Study of Lisdexamfetamine for Bipolar Depression | — | Terminated | — | — | — |
NCT01093963CT.gov Efficacy Study of Lisdexamfetamine to Treat Bipolar Depression | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Bipolar Depression
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Lisdexamfetamine (this asset) | Steward St. Elizabeth's Medical Center of Boston, Inc. | Approved | CC · 40 |
| Lurasidone | NeuroRx, Inc. | P4 | A |
| Lithium, Elemental | Dr. Inge Winter | P4 | BBB |
| Lamotrigine | Stony Brook University | P4 | BBB |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Joshua Rosenblat | P4 | BBB |
| Quetiapine | Dr. Inge Winter | P4 | BBB |
| Escitalopram | Dr. Inge Winter | P4 | BBB |
| Nrx-101 | NeuroRx, Inc. | P3 | BBB |
| Paroxetine | Dr. Inge Winter | P4 | BB |
+42 more in the Bipolar Depression cohort
Other indications for Lisdexamfetamine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Traumatic Brain Injury | — | P4 | CC · 40 |
| Attention Deficit Hyperactivity Disorder, Inattentive Type | — | P4 | CC · 40 |
| Bipolar Disorder | — | P3 | C · 37 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Lisdexamfetamine in Bipolar Depression. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/lisdexamfetamine-bipolar-depression
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