Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Northwell Health
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02800486CT.gov Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Anaplastic Oligoastrocytoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Mannitol (this asset) | Northwell Health | P2 | CCC · 53 |
| Α-Ifn | Sun Yat-sen University | P3 | B |
| Β-Elemene | Sun Yat-sen University | P3 | B |
| Camustine | Shandong Lanjin Pharmaceuticals Co.,Ltd | P3 | B |
| Resiquimod | Jonsson Comprehensive Cancer Center | P2 | B |
| Tandutinib | National Cancer Institute (NCI) | P2 | B |
| Carboplatin | National Cancer Institute (NCI) | P2 | B |
| Dendritic Cells Pulsed With Tumor Lysate | Jonsson Comprehensive Cancer Center | P2 | B |
| Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen Vaccine | Jonsson Comprehensive Cancer Center | P2 | B |
+28 more in the Anaplastic Oligoastrocytoma cohort
Other indications for Mannitol
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cystic Fibrosis | — | P4 | BB · 69 |
| Traumatic Brain Injury | — | P4 | BB · 65 |
| Anaplastic Astrocytoma | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Mannitol in Anaplastic Oligoastrocytoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/mannitol-anaplastic-oligoastrocytoma
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