Floatz Rating
B63/100
Confidence
Indicative
Sponsor
Soligenix
Modality
UNKNOWN
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
52High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06149247CT.gov HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL | — | Completed | — | — | — |
NCT03288818CT.gov Low Dose Total Skin Electron Beam Radiation Therapy and Mechlorethamine Hydrochloride Gel in Treating Patients With Mycosis Fungoides | — | Withdrawn | — | — | — |
NCT03380026CT.gov Mechlorethamine Induced Contact Dermatitis Avoidance Study | — | Completed | — | — | — |
NCT00535470CT.gov An Open Label Study to Evaluate the Safety and Efficacy of Mechlorethamine(MCH) 0.04% Formulation in Mycosis Fungoides | — | Completed | — | — | — |
NCT00168064CT.gov Safety and Efficacy of Nitrogen Mustard in Treatment of Mycosis Fungoides | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Mycosis Fungoides
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Mechlorethamine (this asset) | Soligenix | P2 | B · 63 |
| (+)-Vincristine | Virogen Biotechnology Inc. | P4 | BBB |
| Cyclophosphamide | National Cancer Institute (NCI) | P4 | BBB |
| Fludarabine | National Cancer Institute (NCI) | P2 | BBB |
| Nivestim | Mayo Clinic | P4 | BBB |
| Adriamycin | Pierluigi Porcu | P4 | BBB |
| Etoposide | Fred Hutchinson Cancer Center | P2 | BBB |
| Dexasone | City of Hope Medical Center | P2 | BBB |
| Cyclosporin A | Fred Hutchinson Cancer Center | P2 | BB |
+42 more in the Mycosis Fungoides cohort
Other indications for Mechlorethamine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Lymphoma | — | P3 | B · 59 |
| Central Nervous System Neoplasm | — | P2 | B · 57 |
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Mechlorethamine in Mycosis Fungoides. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/mechlorethamine-mycosis-fungoides
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