Floatz Rating
D30/100
Confidence
Indicative
Sponsor
University of Rochester
Modality
Small molecule
Development Phase
N/A
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
15Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03016806CT.gov Umbilical Cord Blood Transplantation From Unrelated Donors | — | Recruiting | — | — | — |
NCT01598025CT.gov Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Chronic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Melphalan (this asset) | University of Rochester | N/A | D · 30 |
| Cyclophosphamide | Roswell Park Cancer Institute | P4 | BB |
| Busulfanum | University of Rochester | P4 | B |
| Fludarabine | Roswell Park Cancer Institute | P2 | B |
| P.Dom-Wt1-126 Dna Vaccine | University Hospital Southampton NHS Foundation Trust | P2 | B |
| P.Dom-Wt1-37 Dna Vaccine | University Hospital Southampton NHS Foundation Trust | P2 | B |
| Alemtuzumab | Steven E. Coutre | P2 | B |
| Tocilizumab | Medical College of Wisconsin | P1 | CC |
| Nivolumab | Medical College of Wisconsin | P1 | CC |
+4 more in the Chronic Leukemia cohort
Other indications for Melphalan
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diffuse Large B-Cell Lymphoma | — | P4 | BBB · 76 |
| Myelodysplastic/Myeloproliferative Neoplasm | — | P2/3 | BBB · 76 |
| Cancer Of Unknown Primary Site | — | P2/3 | BBB · 72 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Melphalan in Chronic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/melphalan-chronic-leukemia
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