Floatz Rating
C39/100
Confidence
Indicative
Sponsor
The University of Hong Kong
Modality
Small molecule
Development Phase
Early Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
24Indicative
Detailed axis rationale is planned and will be published soon.
No trial-level evidence is linked to this axis yet.
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Osteoarthritis, Knee
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Metformin (this asset) | The University of Hong Kong | Early P1 | C · 39 |
| Duloxetine | Orthopaedic Arthroscopy Knee and Shoulder Clinic | P4 | BBB |
| Naproxen | Pfizer | P3 | BB |
| Remimazolam | Seoul National University Hospital | P4 | BB |
| Dextrose Solution | Kastamonu University | P4 | BB |
| Oxycodone | Riku Antero Palanne | P3 | BB |
| Celecoxib | Pfizer | P4 | BB |
| Dexasone | Poznan University of Medical Sciences | P4 | BB |
| Triamcinolone Hexacetonide | Kastamonu University | P4 | BB |
+40 more in the Osteoarthritis, Knee cohort
Other indications for Metformin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Prediabetes Syndrome | — | P4 | A · 81 |
| Gestational Diabetes | — | P4 | A · 81 |
| Diabetes Mellitus | — | P4 | A · 80 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Metformin in Osteoarthritis, Knee. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/metformin-osteoarthritis-knee
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