Methotrexate
Precursor T-Cell Acute Lymphoblastic Leukemia
Explore 7 assets in Precursor T-Cell Acute Lymphoblastic Leukemia →Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
Therapeutic Advances in Childhood Leukemia Consortium
Modality
Small molecule
Development Phase
Phase 1/2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01483690CT.gov A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Precursor T-Cell Acute Lymphoblastic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Methotrexate (this asset) | Therapeutic Advances in Childhood Leukemia Consortium | P1/2 | CCC · 48 |
| Dexasone | Sanofi | P2 | B |
| Cytarabine | First Affiliated Hospital of Zhejiang University | P2 | CCC |
| Isatuximab | Sanofi | P2 | CCC |
| Ranitidine | Sanofi | P2 | CCC |
| Cephalotaxine 4-Methyl (2R)-2-Hydroxy-2-(4-Hydroxy-4-Methylpentyl)Butanedioate (Ester) | First Affiliated Hospital of Zhejiang University | P2 | CCC |
| Venetoclax | First Affiliated Hospital of Zhejiang University | P2 | CCC |
| Diphenhydramine | Sanofi | P2 | CCC |
| Peripheral Blood Stem Cells, Allogeneic, Cd34 Positive | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | P1/2 | CCC |
+11 more in the Precursor T-Cell Acute Lymphoblastic Leukemia cohort
Other indications for Methotrexate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Adult Acute Lymphoblastic Leukemia | — | P4 | BBB · 77 |
| B-Cell Childhood Acute Lymphoblastic Leukemia | — | P3 | BBB · 76 |
| Acute Promyelocytic Leukemia | — | P3 | BBB · 73 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Methotrexate in Precursor T-Cell Acute Lymphoblastic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 13, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/methotrexate-precursor-t-cell-acute-lymphoblastic-leukemia
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