Modified Vaccinia Virus Ankara Vaccine Expressing P53
Estrogen-Receptor Negative Breast Cancer
Explore 19 assets in Estrogen-Receptor Negative Breast Cancer →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
vaccine
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02432963CT.gov Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Estrogen-Receptor Negative Breast Cancer
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Modified Vaccinia Virus Ankara Vaccine Expressing P53 (this asset) | City of Hope Medical Center | P1 | CC · 43 |
| Carboplatin | Northwestern University | P3 | BBB |
| Pembrolizumab | Massachusetts General Hospital | P2 | BB |
| Epirubicin | Massachusetts General Hospital | P2 | BB |
| Cis-Diamminedichloroplatinum Ii | University of Washington | P3 | BB |
| Cyclophosphamide | Massachusetts General Hospital | P3 | BB |
| Irinotecan | Sanofi | P3 | BB |
| Adriamycin | Roswell Park Cancer Institute | P3 | BB |
| Capecitabine | Kristina A. Fanucci | P3 | BB |
+42 more in the Estrogen-Receptor Negative Breast Cancer cohort
Other indications for Modified Vaccinia Virus Ankara Vaccine Expressing P53
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Ovarian Carcinoma | — | P2 | B · 60 |
| Primary Peritoneal Carcinoma | — | P2 | B · 60 |
| Fallopian Tube Carcinoma | — | P2 | B · 58 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Modified Vaccinia Virus Ankara Vaccine Expressing P53 in Estrogen-Receptor Negative Breast Cancer. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/modified-vaccinia-virus-ankara-vaccine-expressing-p53-estrogen-receptor-negative-breast-cancer
Are you the sponsor?
Submit your data room for a Verified Rating. The public-data rating remains visible alongside.
Contact →