Floatz Rating
D30/100
Confidence
Indicative
Sponsor
Shanghai Jiao Tong University School of Medicine
Modality
UNKNOWN
Development Phase
N/A
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
15Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06141369CT.gov Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001) | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Pancreatic Neuroendocrine Tumor
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Mrna-0523-L001 (this asset) | Shanghai Jiao Tong University School of Medicine | N/A | D · 30 |
| Oxodotreotide | University of Chicago | P4 | BBB |
| Everolimus | Exelixis | P4 | BBB |
| Irinotecan | M.D. Anderson Cancer Center | P2/3 | BB |
| L-Cysteinamide, D-Phenylalanyl-L-Cysteinyl-L-Phenylalanyl-D-Tryptophyl-L-Lysyl-L-Threonyl-N-(2-Hydroxy-1-(Hydroxymethyl)Propyl)-, Cyclic (2->7)-Disulfide, (R-(R*,R*))- | RayzeBio, Inc. | P3 | BB |
| Capecitabine | Gustave Roussy, Cancer Campus, Grand Paris | P3 | BB |
| Zanzalintinib | Exelixis | P3 | BB |
| Fluorouracilum | H. Lee Moffitt Cancer Center and Research Institute | P2/3 | BB |
| Sapanisertib | National Cancer Institute (NCI) | P2 | B |
+41 more in the Pancreatic Neuroendocrine Tumor cohort
Other indications for Mrna-0523-L001
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Adrenal Cortex Carcinoma | — | N/A | D · 30 |
| Medullary Thyroid Gland Carcinoma | — | N/A | D · 30 |
| Thymic Neuroendocrine Carcinoma | — | N/A | NR |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- OxodotreotideUniversity of ChicagoBBB
- EverolimusExelixisBBB
- IrinotecanM.D. Anderson Cancer CenterBB
- L-Cysteinamide, D-Phenylalanyl-L-Cysteinyl-L-Phenylalanyl-D-Tryptophyl-L-Lysyl-L-Threonyl-N-(2-Hydroxy-1-(Hydroxymethyl)Propyl)-, Cyclic (2->7)-Disulfide, (R-(R*,R*))-RayzeBio, Inc.BB
- CapecitabineGustave Roussy, Cancer Campus, Grand ParisBB
Citation
Floatz Terminal. Mrna-0523-L001 in Pancreatic Neuroendocrine Tumor. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/mrna-0523-l001-pancreatic-neuroendocrine-tumor
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