Floatz Rating
BB71/100
Confidence
Indicative
Sponsor
King's College London
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
70High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04977674CT.gov Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine | — | Completed | — | — | — |
NCT04276259CT.gov Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses | — | Completed | — | — | — |
NCT03386448CT.gov The Safety and Efficacy of Naltrexone and Scopolamine Utilized in the Treatment of Major Depression | — | Completed | — | — | — |
NCT04322526CT.gov Study of Naltrexone-Induced Blockade of Antidepressant Effects | — | Completed | — | — | — |
NCT02911597CT.gov Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD) | — | Completed | — | — | — |
NCT00624858CT.gov A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression | — | Completed | — | — | — |
NCT00018824CT.gov Treating Alcohol Use In Older Adults With Depression | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Depressive Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Naltrexone (this asset) | King's College London | Approved | BB · 71 |
| Brexpiprazole | Dr. Albert Kar-Kin Chung | P4 | A |
| Saredutant | Sanofi | P3 | BBB |
| Jnj-54135419 | Chinese PLA General Hospital | P4 | BBB |
| VENLOR | Janssen Research & Development, LLC | P4 | BBB |
| Citalopram | Western University, Canada | P4 | BBB |
| Escitalopram | Poznan University of Medical Sciences | P4 | BBB |
| Fluoxetine | University of Oxford | P4 | BBB |
| Lithium, Elemental | Rakitzi, Stavroula | P4 | BBB |
+42 more in the Depressive Disorder cohort
Other indications for Naltrexone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Alcohol Dependence | — | P4 | BBB · 79 |
| Osteoarthritis | — | P4 | BBB · 75 |
| Rheumatoid Arthritis | — | P4 | BBB · 74 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Naltrexone in Depressive Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/naltrexone-depressive-disorder
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