Floatz Rating
BB69/100
Confidence
Indicative
Sponsor
Endeavor Health
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
67Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06861920CT.gov NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL) | — | Recruiting | — | — | — |
NCT05463367CT.gov Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure | — | Active Not Recruiting | — | — | — |
NCT02528188CT.gov Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Chronic Pain Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Naproxen (this asset) | Endeavor Health | Approved | BB · 69 |
| (±)-Tramadol | EMS | P4 | BBB |
| Lidocaine | National and Kapodistrian University of Athens | P4 | BBB |
| Methadone | Cari Health Inc. | P4 | BBB |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Stanford University | P4 | BBB |
| Fentanyl | Aga Khan University | P4 | BBB |
| Nepenthe | Bursa City Hospital | P4 | BBB |
| Oxycodone | Mayo Clinic | P4 | BBB |
| Buprenorphine | Medical University of South Carolina | P4 | BBB |
+42 more in the Chronic Pain Syndrome cohort
Other indications for Naproxen
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Migraine Disorder | — | P4 | A · 80 |
| Headache Disorder | — | P4 | BBB · 72 |
| Osteoarthritis, Knee | — | P3 | BB · 71 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Naproxen in Chronic Pain Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/naproxen-chronic-pain-syndrome-110218
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