Floatz Rating
D30/100
Confidence
Indicative
Sponsor
Wake Forest University Health Sciences
Modality
Small molecule
Development Phase
N/A
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
15Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05030272CT.gov Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Dysthymic Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Nicotine (this asset) | Wake Forest University Health Sciences | N/A | D · 30 |
| Escitalopram | Nova Scotia Health Authority | P4 | BBB |
| Pramine | New York State Psychiatric Institute | P4 | BBB |
| Fluoxetine | New York State Psychiatric Institute | P4 | BB |
| VENLOR | University of Washington | P4 | BB |
| Armodafinil | Cephalon | P4 | BB |
| Desvenlafaxine | New York State Psychiatric Institute | P4 | BB |
| Duloxetine | New York State Psychiatric Institute | P4 | BB |
| Levodopa | New York State Psychiatric Institute | P4 | BB |
+5 more in the Dysthymic Disorder cohort
Other indications for Nicotine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Nicotine Dependence | — | P4 | A · 83 |
| Cognitive Disorder | — | P2 | BBB · 73 |
| Schizophrenia | — | P4 | BB · 71 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Nicotine in Dysthymic Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/nicotine-dysthymic-disorder
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