Floatz Rating
B60/100
Confidence
Indicative
Sponsor
Alnylam Pharmaceuticals
Modality
nucleic_acid
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
45Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07223203CT.gov TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Familial Amyloid Neuropathy
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Nucresiran (this asset) | Alnylam Pharmaceuticals | P3 | B · 60 |
| Tafamidis | Qilu Pharmaceutical Co., Ltd. | P4 | A |
| Inotersen | Akcea Therapeutics | P4 | BB |
| Revusiran | Alnylam Pharmaceuticals | P3 | BB |
| Patisiran | Alnylam Pharmaceuticals | P3 | BB |
| (1,1'-BIPHENYL)-3-CARBOXYLIC ACID, 2',4'-DIFLUORO-4-HYDROXY- | Boston University | P2/3 | B |
| Aln-Ttrsc02 | Alnylam Pharmaceuticals | P3 | B |
| Nexiguran Ziclumeran | Intellia Therapeutics | P3 | B |
| Acoramidis | Eidos Therapeutics, a BridgeBio company | P3 | B |
+3 more in the Familial Amyloid Neuropathy cohort
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Nucresiran in Familial Amyloid Neuropathy. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/nucresiran-familial-amyloid-neuropathy
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