Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
St. Jude Children's Research Hospital
Modality
UNKNOWN
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04901702CT.gov Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Wilms Tumor
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Onivyde (this asset) | St. Jude Children's Research Hospital | P1/2 | CCC · 48 |
| Adriamycin | Children's National Research Institute | P2 | BB |
| (+)-Vincristine | Centre Oscar Lambret | P2 | BB |
| Itraconazole | Samsung Medical Center | P4 | BB |
| Irinotecan | Centre Oscar Lambret | P2 | BB |
| Nivestim | Barbara Ann Karmanos Cancer Institute | P3 | BB |
| Cyclophosphamide | St. Jude Children's Research Hospital | P2 | BB |
| Etoposide | Centre Oscar Lambret | P2 | BB |
| Calcium Phosphate | Children's Oncology Group | P3 | BB |
+42 more in the Wilms Tumor cohort
Other indications for Onivyde
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Malignant Pancreatic Neoplasm | — | P2 | B · 57 |
| Ewing Sarcoma | — | P1/2 | CCC · 48 |
| Hepatoblastoma | — | P1/2 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Onivyde in Wilms Tumor. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/onivyde-wilms-tumor
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