Floatz Rating
BB65/100
Confidence
Indicative
Sponsor
Imperial College London
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
54Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01847651CT.gov Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hepatic Encephalopathy
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Ornithine (this asset) | Imperial College London | Approved | BB · 65 |
| Rifaximin | General Hospital of Shenyang Military Region | P4 | BBB |
| L-Ornithine L-Aspartate | Jinnah Postgraduate Medical Centre | P4 | BBB |
| Lactulose | General Hospital of Shenyang Military Region | P4 | BBB |
| Normal Human Serum Albumin | General Hospital of Shenyang Military Region | P4 | BB |
| L-Ornithine-L-Aspartate | Qurratul Ain Jamil | P4 | BB |
| Lactose | Centro Regional para el Estudio de las Enfermedades Digestivas | P4 | BB |
| Blood, Whole | Imperial College London | P4 | BB |
| Carvedilol | West China Hospital | P4 | BB |
+38 more in the Hepatic Encephalopathy cohort
Other indications for Ornithine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cirrhosis Of Liver | — | P2/3 | BB · 67 |
| Esophageal Varices With Bleeding | — | P2/3 | B · 61 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Ornithine in Hepatic Encephalopathy. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/ornithine-hepatic-encephalopathy
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