Floatz Rating
B63/100
Confidence
Indicative
Sponsor
University of South Florida
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
58High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06581003CT.gov Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury | — | Recruiting | — | — | — |
NCT06665633CT.gov Treatment of U.S. Veterans With Mild Traumatic Brain Injury With Hyperbaric Oxygen Therapy | — | Completed | — | — | — |
NCT02407028CT.gov Hyperbaric Oxygen Brain Injury Treatment Trial | — | Recruiting | — | — | — |
NCT01986205CT.gov Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury | — | Completed | — | — | — |
NCT02089594CT.gov Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS) | — | Unknown | — | — | — |
NCT01847755CT.gov Hyperbaric Treatment of Traumatic Brain Injury (TBI) | — | Completed | — | — | — |
NCT01611194CT.gov mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms | — | Completed | — | — | — |
NCT01430325CT.gov Test of Chamber Pressure to Divers and Chamber Attendants | — | Completed | — | — | — |
NCT01306968CT.gov Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) | — | Completed | — | — | — |
NCT00760734CT.gov Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD) | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Traumatic Brain Injury
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Oxygen (this asset) | University of South Florida | P3 | B · 63 |
| Melatonin | Children's National Research Institute | P4 | BBB |
| Apsolol | Tanta University | P4 | BBB |
| Nepenthe | Henry M. Jackson Foundation for the Advancement of Military Medicine | P4 | BB |
| Amantadine | SHINKEI Therapeutics, Inc | P4 | BB |
| Dexmedetomidine | Universitas Jenderal Soedirman | P4 | BB |
| Fentanyl | Henry M. Jackson Foundation for the Advancement of Military Medicine | P4 | BB |
| Dextromethorphan | Avanir Pharmaceuticals | P4 | BB |
| VENLOR | Virginia Commonwealth University | P4 | BB |
+42 more in the Traumatic Brain Injury cohort
Other indications for Oxygen
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Anxiety Disorder | — | P4 | BB · 66 |
| Benign Prostatic Hyperplasia | — | P4 | BB · 66 |
| Prostate Disorder | — | P4 | BB · 66 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Oxygen in Traumatic Brain Injury. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/oxygen-traumatic-brain-injury
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