Floatz Rating
CC47/100
Confidence
Indicative
Sponsor
Gradalis, Inc.
Modality
nucleic_acid
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02736565CT.gov Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Ewing Sarcoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pbi-Shrna™ Ews/Fli1 Type 1 Lipoplex (this asset) | Gradalis, Inc. | P1 | CC · 47 |
| Irinotecan | Milton S. Hershey Medical Center | P3 | BB |
| Nivolumab | Children's National Research Institute | P2 | B |
| Cyclophosphamide | Essen Biotech | P2 | B |
| Nogitecan | Pfizer | P2 | B |
| Adriamycin | Children's National Research Institute | P2 | B |
| Nadravaleucel | Brenda Cooper, MD | P2 | B |
| Gemogenovatucel-T | Gradalis, Inc. | P3 | B |
| Palbociclib | Dana-Farber Cancer Institute | P2 | B |
+42 more in the Ewing Sarcoma cohort
Other indications for Pbi-Shrna™ Ews/Fli1 Type 1 Lipoplex
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Rare | — | P1 | CC · 47 |
| Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | — | P1 | CC · 47 |
| Sarcoma | — | P1 | CC · 42 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pbi-Shrna™ Ews/Fli1 Type 1 Lipoplex in Ewing Sarcoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pbi-shrna-ewsfli1-type-1-lipoplex-ewing-sarcoma
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