Pegaspargase
Acute Leukemia Of Ambiguous Lineage
Explore 43 assets in Acute Leukemia Of Ambiguous Lineage →Floatz Rating
B58/100
Confidence
Indicative
Sponsor
Janssen Research & Development, LLC
Modality
protein_peptide
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05521087CT.gov A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias | — | Withdrawn | — | — | — |
NCT02828358CT.gov Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Leukemia Of Ambiguous Lineage
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pegaspargase (this asset) | Janssen Research & Development, LLC | P2 | B · 58 |
| L-Ofloxacin | Children's Oncology Group | P3 | BB |
| Cyclophosphamide | SWOG Cancer Research Network | P2 | BB |
| Cytarabine | SWOG Cancer Research Network | P2 | B |
| Vincristine Sulfate | Children's Oncology Group | P2 | B |
| Fludarabine | Janssen Research & Development, LLC | P2 | B |
| Methotrexate | SWOG Cancer Research Network | P2 | B |
| (+)-Vincristine | SWOG Cancer Research Network | P2 | B |
| Dexasone | SWOG Cancer Research Network | P2 | B |
+42 more in the Acute Leukemia Of Ambiguous Lineage cohort
Other indications for Pegaspargase
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| B-Cell Childhood Acute Lymphoblastic Leukemia | — | P3 | A · 80 |
| Extranodal Nasal NK/T Cell Lymphoma | — | P4 | BBB · 76 |
| Non-Hodgkin Lymphoma | — | P4 | BBB · 75 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pegaspargase in Acute Leukemia Of Ambiguous Lineage. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pegaspargase-acute-leukemia-of-ambiguous-lineage
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