Floatz Rating
BB68/100
Confidence
Indicative
Sponsor
Syndax Pharmaceuticals
Modality
protein_peptide
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
58High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05326516CT.gov A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia | — | Completed | — | — | — |
NCT00557193CT.gov Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | — | Completed | — | — | — |
NCT00061945CT.gov Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Undifferentiated Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pegaspargase (this asset) | Syndax Pharmaceuticals | P3 | BB · 68 |
| Fludarabine | Fred Hutchinson Cancer Center | P2 | BB |
| Vincristine Sulfate | M.D. Anderson Cancer Center | P3 | BB |
| Cyclophosphamide | Masonic Cancer Center, University of Minnesota | P3 | BB |
| Cytarabine | Fred Hutchinson Cancer Center | P3 | BB |
| Dexasone | Therapeutic Advances in Childhood Leukemia Consortium | P3 | BB |
| Nivestim | Fred Hutchinson Cancer Center | P3 | BB |
| Daunomycin | Syndax Pharmaceuticals | P3 | BB |
| Methotrexate | Therapeutic Advances in Childhood Leukemia Consortium | P3 | BB |
+42 more in the Acute Undifferentiated Leukemia cohort
Other indications for Pegaspargase
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| B-Cell Childhood Acute Lymphoblastic Leukemia | — | P3 | A · 80 |
| Extranodal Nasal NK/T Cell Lymphoma | — | P4 | BBB · 76 |
| Non-Hodgkin Lymphoma | — | P4 | BBB · 75 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pegaspargase in Acute Undifferentiated Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pegaspargase-acute-undifferentiated-leukemia
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