Floatz Rating
CCC54/100
Confidence
Indicative
Sponsor
Merck Sharp & Dohme LLC
Modality
UNKNOWN
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05007106CT.gov MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Cholangiocarcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pembrolizumab/Vibostolimab Coformulation (this asset) | Merck Sharp & Dohme LLC | P2 | CCC · 54 |
| Fluorouracilum | Jonsson Comprehensive Cancer Center | P3 | BB |
| Irinotecan | Jonsson Comprehensive Cancer Center | P3 | B |
| Docetaxel | Merck Sharp & Dohme LLC | P2 | B |
| Oxaliplatin | Jonsson Comprehensive Cancer Center | P3 | B |
| Etomidate | Cheju Halla General Hospital | P4 | B |
| Midazolam | Cheju Halla General Hospital | P4 | B |
| Trametinib | National Cancer Institute (NCI) | P2 | B |
| Meperidine | Cheju Halla General Hospital | P4 | B |
+42 more in the Cholangiocarcinoma cohort
Other indications for Pembrolizumab/Vibostolimab Coformulation
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Endometrial Cancer | — | P2 | B · 57 |
| Urinary Bladder Neoplasm | — | P2 | B · 57 |
| Uterine Cervix Neoplasm | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pembrolizumab/Vibostolimab Coformulation in Cholangiocarcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pembrolizumabvibostolimab-coformulation-cholangiocarcinoma
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