Floatz Rating
B57/100
Confidence
Indicative
Sponsor
Vaccinex Inc.
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02481674CT.gov A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Huntington Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pepinemab (this asset) | Vaccinex Inc. | P2 | B · 57 |
| Deutetrabenazine | Teva Branded Pharmaceutical Products R&D LLC | P4 | BBB |
| Tetrabenazine | William Ondo, MD | P4 | BBB |
| Tominersen | Hoffmann-La Roche | P3 | BBB |
| Latrepirdine | Medivation, Inc. | P3 | BB |
| Pridopidine | Prilenia | P3 | BB |
| MT-5199 | Neurocrine Biosciences | P3 | BB |
| Memantine | University of British Columbia | P4 | BB |
| Cellavita-Hd | Azidus Brasil | P2/3 | BB |
+42 more in the Huntington Disease cohort
Other indications for Pepinemab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Head And Neck Squamous Cell Carcinoma | — | P1/2 | CCC · 52 |
| Osteosarcoma | — | P1/2 | CCC · 52 |
| Refractory Malignant Neoplasm | — | P1/2 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pepinemab in Huntington Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pepinemab-huntington-disease
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