Floatz Rating
CCC50/100
Confidence
Indicative
Sponsor
Assiut University
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05346666CT.gov Possible Immuno-Modulatory Effect of Tocilizumab in Patients With Refractory Status Epilepticus. | — | Unknown | — | — | — |
NCT03196466CT.gov Population Pharmacokinetics of Antiepileptic in Pediatrics | — | Completed | — | — | — |
NCT02726867CT.gov Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus | — | Withdrawn | — | — | — |
NCT01284556CT.gov Evaluation Phenobarbital as Adjunctive Therapy in Participants With Partial Onset Seizures | — | Completed | — | — | — |
NCT00530413CT.gov Study of Phenobarbital Inhibition of Catamenial Epilepsy | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Epilepsy
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Phenobarbital (this asset) | Assiut University | P3 | CCC · 50 |
| Topiramate | Université de Sherbrooke | P4 | BBB |
| Levetiracetam | Beijing Tiantan Hospital | P4 | BBB |
| Neurotop | Assistance Publique - Hôpitaux de Paris | P4 | BBB |
| Eslicarbazepine Acetate | Bial - Portela C S.A. | P4 | BBB |
| Lamotrigine | Assiut University | P4 | BBB |
| Lacosamide | Second Affiliated Hospital of Guangzhou Medical University | P4 | BBB |
| Valproic Acid | Sanofi | P4 | BBB |
| Midazolam | Haseki Training and Research Hospital | P4 | BBB |
+42 more in the Epilepsy cohort
Other indications for Phenobarbital
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Traumatic Brain Injury | — | P4 | CCC · 53 |
| Brain Ischemia | — | P4 | CCC · 53 |
| Brain Hypoxia - Ischemia | — | P4 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Phenobarbital in Epilepsy. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/phenobarbital-epilepsy
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