Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Brown University
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05655598CT.gov TAS-116 Plus Palbociclib in Breast and Rb-null Cancer | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Retinoblastoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pimitespib (this asset) | Brown University | P1 | CC · 43 |
| Nivestim | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | P4 | BBB |
| Itraconazole | Samsung Medical Center | P4 | BB |
| Thiotepa | Masonic Cancer Center, University of Minnesota | P2 | BB |
| Cyclophosphamide | Seattle Children's Hospital | P2 | BB |
| Busulfanum | Masonic Cancer Center, University of Minnesota | P2 | BB |
| Carboplatin | Masonic Cancer Center, University of Minnesota | P2 | BB |
| Nogitecan | Emory University | P2 | BB |
| Gm-Csf | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | P4 | B |
+20 more in the Retinoblastoma cohort
Other indications for Pimitespib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Refractory Malignant Neoplasm | — | P1 | CC · 43 |
| Alveolar Soft Part Sarcoma | — | P1 | CC · 43 |
| Small Cell Lung Carcinoma | — | P1 | CC · 41 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pimitespib in Retinoblastoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pimitespib-retinoblastoma
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