Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
The University of Texas Health Science Center at San Antonio
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05838287CT.gov Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Diastolic Heart Failure
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pioglitazone (this asset) | The University of Texas Health Science Center at San Antonio | Approved | BB · 64 |
| Semaglutide | Mayo Clinic | P4 | BBB |
| Metformin | Sara ElAdawy | P4 | BBB |
| Tirzepatide | Yunlong Wang | P4 | BBB |
| Liraglutide | Leiden University Medical Center | P4 | BBB |
| Benzbromarone | National Defense Medical Center, Taiwan | P4 | BB |
| Febuxostat | National Defense Medical Center, Taiwan | P4 | BB |
| Tadalafil | Kafrelsheikh University | P4 | BB |
| Bydureon | Baylor Research Institute | P3 | BB |
+15 more in the Diastolic Heart Failure cohort
Other indications for Pioglitazone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diabetes Mellitus | — | P4 | BBB · 79 |
| Metabolic Dysfunction-Associated Steatohepatitis | — | P4 | BBB · 75 |
| Abdominal Obesity-Metabolic Syndrome | — | P4 | BBB · 73 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pioglitazone in Diastolic Heart Failure. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pioglitazone-diastolic-heart-failure
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