Floatz Rating
C39/100
Confidence
Indicative
Sponsor
Rambam Health Care Campus
Modality
Small molecule
Development Phase
Early Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
24Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05753657CT.gov A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer. | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hyperinsulinism
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pioglitazone (this asset) | Rambam Health Care Campus | Early P1 | C · 39 |
| Metformin | Attikon Hospital | P4 | BB |
| Eudemine Injection | Columbia University | P2 | B |
| Rosiglitazone | New York Medical College | P2 | B |
| Insulin-Like Growth Factor I | Children's Hospital of Philadelphia | P2 | B |
| Vigabatrin | University of Arizona | P2 | CCC |
| Pasireotide | Montefiore Medical Center | P2 | CCC |
| Glucagon | Columbia University | P1 | CC |
| L-Cysteinamide, D-Phenylalanyl-L-Cysteinyl-L-Phenylalanyl-D-Tryptophyl-L-Lysyl-L-Threonyl-N-(2-Hydroxy-1-(Hydroxymethyl)Propyl)-, Cyclic (2->7)-Disulfide, (R-(R*,R*))- | Columbia University | P1 | CC |
+15 more in the Hyperinsulinism cohort
Other indications for Pioglitazone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diabetes Mellitus | — | P4 | BBB · 79 |
| Metabolic Dysfunction-Associated Steatohepatitis | — | P4 | BBB · 75 |
| Abdominal Obesity-Metabolic Syndrome | — | P4 | BBB · 73 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pioglitazone in Hyperinsulinism. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pioglitazone-hyperinsulinism
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